Relationship Between Serum MBP and LDH Levels and Bleeding Transformation After rt-PA Thrombolytic Therapy in Patients with Acute Cerebral Infarct
KANG Hui
WANG Qian
Abstract：Objective To explore the relationship between serum levels of myelin basic protein(MBP)and lactatedehydrogenase(LDH)and bleeding transformation after thrombolytic therapy with recombinant human tissue plasminogen activator(rt-PA)in patients with acute cerebral infarct(ACI).Methods A retrospective analysis was conducted on the clinical data of 97 ACI patients in Luohe Central Hospital from March 2022 to March 2024.All patients were tested for serum MBP and LDH levels upon admission,and were divided into a hemorrhagic conversion group(11 cases)and a non hemorrhagic conversion group(86 cases)based on whether there was bleeding conversion in the head CT scan 24 hours after thrombolysis.The relationship between serum MBP,LDH and hemorrhagic transformation after rt-PA thrombolytic therapy in ACI patients was analyzed.The receiver operating characteristic(ROC)curve was drawn to analyze the value of serum MBP and LDH levels in predicting hemorrhagic transformation after rt-PA thrombolytic therapy in ACI patients.Results The National Institutes of Health stroke scale(NIHSS)score of the hemorrhagic conversion group was higher than that of the non hemorrhagic conversion group,and the proportion of atrial fibrillation was higher than that of the non hemorrhagic conversion group(P＜0.05).The serum MBP and LDH levels in the hemorrhagic transformation group were higher than those in the non hemorrhagic transformation group(P＜0.05).Through point two column correlation analysis,the results showed a positive correlation between serum MBP and LDH levels and bleeding transformation in ACI patients after rt-PA thrombolysis treatment(r＞0,P＜0.05).ROC curve results showed that serum MBP and LDH detection had certain predictive value for hemorrhagic transformation,and the combined predictive value was higher.Conclusion The levels of serum MBP and LDH are closely related to the transformation of bleeding in ACI patients after rt-PA thrombolysis treatment,and have certain predictive value.
Keywords：acute cerebral infarctrecombinant tissue plasminogen activator thrombolysishemorrhagic transformationmyelin basic proteinlactate dehydrogenase
Publication Date：2025-08-13
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 2770-2773 )