Diagnostic Value of US-FNAC Combined with BRAF V600E Gene Test for Thyroid Cancer
FU Jingjie
WEI Na
SHI Yinhua
QIN Mengke
XU Jingjing
Abstract：Objective To investigate the value of ultrasound-guided fine needle aspiration cytology(US-FNAC)and US-FNAC combined with BRAF V600E gene for the diagnosis of thyroid cancer,and to calculate the risk of malignancy(ROM)of various categories TBSRTC cytology with histopathology as the gold standard.Methods A total of 6 010 patients who underwent US-FNAC examination at the First Affiliated Hospital of Zhengzhou University from January 2021 to January 2022 were retrospectively analyzed,and BRAF V600E gene testing was performed on these patients,among which 1 628 patients with histopathological findings were included in the study.The specificity,sensitivity,positive predictive value and negative predictive value of US-FNAC and US-FNAC combined with BRAF V600E gene for thyroid cancer diagnosis were analyzed.The x2 test was used to compare the statistical significance of the differences between the two diagnostic methods of US-FNAC combined with BRAF V600E gene and US-FNAC.The US-FNAC results were classified into TBSRTC cytology categories Ⅰ-Ⅵ,and the ROM values were calculated for each category.Results The sensitivity,specificity,positive predictive value,negative predictive value and area under the curve(AUC)values of US-FNAC,and US-FNAC combined with BRAF V600E for the diagnosis of thyroid cancer were 91.9％,61.8％,98.6％,21.0％and 0.768;97.4％,69.4％,99.0％,45.3％and 0.796,respectively.The x2 test was used to analyze the two diagnostic methods,US-FNAC combined with BRAF V600E gene and US-FNAC alone,and the differences were statistically significant(x2=711.481,P＜0.001).The ROM values for TBSRTC cytology classes Ⅰ-Ⅵ ranged from 3.3％to 71.7％,1.3％to 62.1％,17.6％to 94.3％,5.6％to 33.3％,50.5％to 98.2％,and 49.9％to 99.3％,respectively.Conclusion US-FNAC combined with BRAF V600E gene can improve the diagnostic efficacy of thyroid cancer compared with US-FNAC alone.
Keywords：thyroid cancerBRAF V600E gene testultrasound-guided fine needle aspiration cytologydiagnostic value
Publication Date：2025-07-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 2540-2543 )