Value of Peripheral Blood PCT,NLR,SII Combined with CPIS Score in the Diagnosis and Prognosis Assessment of Post-stroke Pulmonary Infection

LIAO Yuan; SUO Guanghui; ZHANG Bo

doi:10.3969/j.issn.1004-437X.2025.13.015

Abstract：Objective To explore the value of peripheral blood procalcitonin(PCT),neutrophil/lymphocyte ratio(NLR),systemic immunoinflammatory index(SII)combined with clinical pulmonary infection score(CPIS)in the diagnosis and prognosis assessment of post-stroke pulmonary infection.Methods A total of 126 patients with stroke admitted to Luoyang Sixth People's Hospital from May 2020 to March 2023 were selected and divided into infected group(65 cases)and non-infected group(61 cases)according to whether pulmonary infection occurred.The peripheral blood PCT,NLR,SII and CPIS score of all patients were recorded,and the predictive value of the above indicators on post-stroke pulmonary infection and prognosis was analyzed by receiver operating characteristic(ROC)curve.Results The peripheral blood PCT,NLR,SII and CPIS score in infected group were higher than those in non-infected group(P＜0.05).ROC curve analysis showed that peripheral blood PCT,NLR,SII and CPIS score and their combination had predictive efficiency on post-stroke pulmonary infection(P＜0.05),and their area under the curve(AUC)were 0.892,0.955,0.959,0.923 and 0.985 respectively.The combined detection had the highest efficiency,with sensitivity of 98.46％ and specificity of 100.00％.The peripheral blood PCT,NLR,SII and CPIS score were manifested as good prognosis group＜poor prognosis group＜death group(P＜0.05).ROC curve analysis revealed that peripheral blood PCT,NLR,SII and CPIS score and their combination were effective in predicting the prognosis of post-stroke pulmonary infection(P＜0.05),and their AUC were 0.631,0.651,0.668,0.750 and 0.849 respectively,and the combination efficiency was the highest with sensitivity of 75.00％and specificity of 100.00％.Conclusion Peripheral blood PCT,NLR,SII and CPIS score have high diagnostic efficiency in the diagnosis and prognosis assessment of post-stroke pulmonary infection,but the combined diagnosis has the highest efficiency.