Value of Electrocardiogram QRS Wave Duration Combined with Serum TRPC1 and TSG-6 Levels in Detecting the Prognosis of Patients with Chronic Heart Failure
WANG Min
Abstract：Objective To observe the QRS duration of electrocardiogram,serum levels of tumor necrosis factor-α stimulating gene-6(TSG-6)and transient receptor potential channel protein 1(TRPC1)in patients with chronic heart failure(CHF),and to analyze their correlation with prognosis and its predictive value for prognosis.Methods A retrospective analysis was conducted on 106 CHF patients admitted to Zhengzhou Central Hospital from January 2021 to January 2023(as the study group),and another 106 healthy volunteers from the same period were selected as the control group.The QRS duration of electrocardiogram,serum TRPC1,and TSG-6 levels were compared among patients with different functional grades,and their correlation with poor prognosis was analyzed to evaluate their predictive value for patient prognosis.Results The QRS duration of electrocardiogram in the study group was higher than that in the control group,and the serum levels of TRPC 1 and TSG-6 were higher than that in the control group(P＜0.05),with the increase of cardiac function classification,QRS duration and serum levels of TRPC1and TSG-6 showed an upward trend(P＜0.05).QRS duration and serum levels of TRPC1and TSG-6 in patients with poor prognosis were higher than those with good prognosis(P＜0.05).Partial correlation analysis showed that QRS duration of electrocardiogram and serum levels of TRPC1 and TSG-6 were positively correlated with poor prognosis(P＜0.05).The area under the curve of QRS duration of electrocardiogram and serum levels of TRPC 1 and TSG-6 in predicting prognosis was greater than that of single index(P＜0.05).Conclusion QRS duration of electrocardiogram and serum levels of TRPC1and TSG-6 are positively correlated with poor prognosis in patients with CHF,and have certain predictive value for poor prognosis.Combined detection of their levels can improve the predictive efficiency.
Keywords：chronic heart failureQRS wave durationtumor necrosis factor alpha stimulated gene-6transient receptor potential channel protein 1prognosis
Publication Date：2025-06-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 2167-2171 )