Expression of miR-92b in Esophageal Cancer Patients and Its Correlation with Clinical Prognosis
YU Zhaoya
LU Weiwei
ZHANG Mengwei
CHEN Dong
Abstract：Objective To investigate the expression of miR-92b in esophageal cancer patients and its correlation with clinical prognosis.Methods A prospective study was conducted,selecting 94 patients diagnosed with esophageal cancer after surgical treatment and postoperative pathology from January 2020 to January 2021 as the study subjects.The expression levels of miR-92b in cancer tissues and adjacent tissues were detected by real-time fluorescence quantitative PCR.The relationship between miR-92b expression and different tissues was tested by point two column correlation.Patients were followed up for 18 months and divided into a mortality group and a survival group based on their prognostic outcomes.The differences in miR-92b levels in cancer tissues between the two groups were compared,and the relationship between miR-92b expression and patient prognosis was tested using point binary correlation.The receiver operating characteristic(ROC)curve was then plotted,and the predictive value of miR-92b on the prognosis of esophageal cancer patients was analyzed using area under curve(AUC).Results The relative expression level of miR-92b in cancer tissue was significantly lower than that in adjacent tissues,with a statistical significant difference(P＜0.05).According to the point two column correlation test,there was a negative correlation between the relative expression level of miR-92b and different tissues(r＜0,P＜0.05).Patients were followed up for 18 months,and out of 94 patients,37 died,with a mortality rate of 39.36％.The relative expression level of miR-92 b in cancer tissue of patients in the mortality group was significantly lower than that of the survival group,with a statistical significant difference(P＜0.05).According to the point two column correlation test,there was a negative correlation between the relative expression level of miR-92b and the prognosis of esophageal cancer patients(r＜0,P＜0.05).ROC showed that miR-92b had a good predictive value for the prognosis of patients with esophageal cancer,and the AUC was 0.884.Conclusion The relative expression level of miR-92b in esophageal cancer patients shows a low level in cancer tissue,and it can effectively predict patient prognosis.
Keywords：microribonucleic acid-92besophageal cancerprognosiscorrelation
Publication Date：2025-05-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 1793-1797 )