Risk Analysis of Cerebrovascular Disease-Specific Mortality of Lung Adenocarcinoma Based on SEER Database

XU Zhixiu; LI Zhuoran

doi:10.3969/j.issn.1004-437X.2025.10.003

Abstract：Objective To evaluate the risk of cerebrovascular disease-specific mortality in those patients.Methods Patients with lung adenocarcinoma diagnosed from 2016 to 2020 were extracted from the U.S.Surveillance,Epidemiology,and End Results database.Standardized mortality ratio(SMR)was used to estimate the risk of cerebrovascular disease-specific death.Results A total of 65 101 patients with lung adenocarcinoma were enrolled,and 316 of them died of cerebrovascular disease.The cumulative mortality rate of cerebrovascular disease was 0.49％,and the SMR of cerebrovascular disease was 2.26(95％CI:2.01-2.52,P＜0.001).According to the subgroup analysis,patients under 60 years old had a higher SMR than the other age groups(8.44,95％CI:5.91-11.68,P＜0.001).Patients with distant stage had a higher SMR than those with other stages(3.61,95％CI:3.12-4.16,P＜0.001).Patients with brain metastasis had a higher SMR than those without brain metastasis(4.79,95％CI:3.53-6.35,P＜0.001).Patients with bone metastasis had a higher SMR than those without bone metastasis(4.01,95％CI:3.10-5.12,P＜0.001).Patients with liver metastasis had a higher SMR than those without liver metastasis(5.14,95％CI:3.33-7.59,P＜0.001).Patients with lung metastasis had a higher SMR than those without lung metastasis(3.79,95％CI:2.87-4.89,P＜0.001).Conclusion The cumulative mortality of cerebrovascular disease in lung adenocarcinoma is low,but the risk of cerebrovascular disease-specific death is higher than that in the general population.The SMR of patients under 60 years old,distant stage,and liver metastasis is higher than that of other corresponding subgroups,so active prevention should be carried out for this population.