Relationship Between Four Lipid Components and Early Age-Related Macular Degeneration Based on Mendelian Randomization
ZHENG Chunyan
NAN Anchao
Abstract：Objective To analyze the relationship between four lipid components[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]in blood and early age-related degeneration of macula(AMD)by using a two sample Mendelian randomization(MR)method.Methods This study searched the genome-wide association study(GWAS)database and selected genetic loci closely related to four lipid components as instrumental variables.The inverse variance weighted(IVW)method was used as the main method,and weighted median(WME),MR Egger regression,simple single mode method,and weighted mode method were used as auxiliary methods to perform two sample MR analysis on the data.Evaluate the relationship between four lipid components and early AMD,using OR values as evaluation indicators.To ensure the reliability and stability of the results,heterogeneity tests,gene pleiotropy tests,and sensitivity analyses were simultaneously carried out.Results The results showed that HDL-C could increase the risk of early AMD(OR=1.21,95％CI:1.11～1.31,P＜0.05),while there was no correlation between the other three lipids TC,TG,LDL-C with the risk of early AMD(OR＜1,P＜0.05).Conclusion HDL-C may increase the risk of early AMD,suggesting that we can monitor the HDL-C levels of early AMD patients and provide a new research perspective for us to further clarify the pathogenesis of AMD.
Keywords：age-related degeneration of maculaearly stageMendelian randomizationtriglyceridestotal cholesterollow-density lipoprotein cholesterolhigh-density lipoprotein cholesterol
Publication Date：2025-04-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：7( 1345-1351 )