Effect of Early Immune-Enhancing Enteral Nutrition Combined with Live Bacteria Preparation on Malnourished Ulcerative Colitis Patients

GONG Xiaolin; ZHANG Qiuli; ZHAO Bin

doi:10.3969/j.issn.1004-437X.2025.07.020

Abstract：Objective To investigate the effect of live bacteria preparation combined with early immune-enhacing enteral nutrition on the body immunity and intestinal mucosal barrier in patients with malnutrition ulcerative colitis(UC).Methods A total of 87 UC patients in Puyang People's Hospital from January 2022 to January 2024 were selected and divided them into two groups according to different treatment plans.Among them,43 patients who received regular enteral nutrition combined with live bacteria preparations were in the control group,and 44 patients who received immune-enhancing enteral nutrition combined with live bacteria preparations were in the study group.The curative effect,nutritional status[hemoglobin(Hb),prealbumin(PA),albumin(ALB)],intestinal mucosal barrier function[diamine oxidase(DAO),D-lactic acid(D-LA),endotoxin(ET)],immune function[complement C3,immunoglobulin A(IgA),IgG]and adverse reactions were compared between the two groups.Results The total effective rate of the study group(93.18％)was higher than that of the control group(76.74％)(P＜0.05).After 14 days of treatment,Hb,ALB and PA in the study group were higher than those in the control group(P＜0.05).After 14 days of treatment,DAO,ET and D-LA in the study group were lower than those in the control group(P＜0.05).After 14 days of treatment,IgA and IgG in the study group were higher than those in the control group,while complement C3 was lower than that in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(2.27％vs 9.30％)(P＞0.05).Conclusion The treatment of malnutrition in UC with immune-enhancing enteral nutrition combined with live bacterial preparations has significant therapeutic effects,improving nutritional status,intestinal mucosal barrier function,and immune function,with high safety.