Meta-Analysis of the Effectiveness and Safety of Repetitive Transcranial Magnetic Stimulation in the Treatment of Obsessive-Compulsive Disorder
LI Wenfeng
ZHU Junjing
JIA Dehuan
WANG Shuxian
SONG Yanyan
KONG Derong
LI Meng
Abstract：Objective Systematic evaluation of the efficacy and safety of repetitive transcranial magnetic stimulation(rTMS)in the treatment of obsessive-compulsive disorder(OCD).Methods The computer searched PubMed,Cochrane Library,Embase,Web of Science,CNKI,Wanfang Database,VIP Chinese Science and Technology Journal,and SinoMed Database to search all randomized controlled trials(RCTs)for rTMS treatment of OCD.The search time limit was from the database establishment to October 14,2023.After 2 independent researchers screened literature,extracted the required data and evaluated the risk of bias in the included study,meta-analysis was performed using RevMan 5.4 and Stata 17.0 software after the study was performed.Results The study included 22 RCTs,involving 942 OCD patients,481 in the treatment group and 461 in the control group.The results of meta analysis showed that after treatment,the combined Hedges's g of Yale-Brown obsessive-compulsive scale(Y-BOCS)of the two groups was-0.51(95％CI:-0.87--0.34,Z=-5.46,P＜0.01).Subgroup analysis showed that the Hedges's g of the combined 1 Hz group was-0.61(95％CI:-0.69--0.33,Z=33.47,P＜0.01),and the Hedges's g of stimulating the granular dorsolateral prefrontal cortex(DLPFC)brain area was-0.70(95％CI:-1.02--0.39,Z=26.65,P＜0.01).After treatment,the combined Hedges's g of Hamilton anxiety scale(HAMA)score of the two groups was-0.57(95％CI:-0.80--0.34,Z=-4.86,P＜0.01).The OR value of the combined withdrawal rate of the two groups was 0.17(95％CI:-0.38-0.73,Z=0.60,P=0.55).Conclusion rTMS is effective in the treatment of OCD with few adverse reactions,especially in the frequency of 1 Hz and stimulating the brain area of DLPFC.
Keywords：obsessive-compulsive disorderrepetitive transcranial magnetic stimulationmeta-analysisrandomised controlled trial
Publication Date：2025-04-13
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：7( 1161-1167 )