Establishment and Capacity Analysis of Platelet Donor Bank with Known HLA and HPA Genotype in Henan
LIU Zheng
WANG Ziqing
SUN Yamin
KANG Yiqing
DU Juan
LI Jianbin
Abstract：Objective To analyze the capacity and matching probability of platelet human leukocyte antigen(HLA)and human platelet antigen(HPA)gene donor banks in Henan region.Methods A total of 1 445 platelet donors from Henan province were selected as the study subjects.HPA-1-6,-10,-15,-21 and HLA-A,-B gene typing were performed using multiple fluorescence PCR method.The gene frequency,haplotype frequency and phenotype frequency of HLA/HPA was performed with Arlequin 3.5.2.2 software.The storage capacity level was evaluated.Results Among 1 445 platelet donors with known HLA and HPA genotype,the probability of finding one donor with full-matched HPA genotypes was calculated to be 91％.The probability of finding one donor with the matching HLA-A,-B haplotype was 66％.The probability of finding a donor with matching HLA phenotype was 25％.Conclusion The HLA and HPA gene donor database has been established in Henan,and the distribution of HLA and HPA genes in Henan province has been analyzed.Providing the data support for the construction,maintenance and application of platelet HLA and HPA gene donor banks in the region.
Keywords：human leukocyte antigenhuman platelet antigenplatelet transfusion refractorinessplatelet donor bank
Publication Date：2025-04-13
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 1153-1157 )