Diagnostic Value of Transient Elastography Combined with Serum γ-Glutamyl Transferase in Children with Biliary Atresia

ZHU Yingying; GENG Hehong; WAN Yuanyuan; YAN Lin; ZHAO Huanhuan; ZHANG Xianwei

doi:10.3969/j.issn.1004-437X.2025.06.012

Abstract：Objective To explore the diagnostic value of combination of transient elastography and serum γ-glutamyl transferase in evaluating children with biliary atresia.Methods From March 2019 to March 2021,88 children with suspected noninfectious cholestatic liver disease were selected from the Department of General Surgery of Children's Hospital of Henan Province,including 20 children with cholestasis and 68 children with biliary atresia.All children were diagnosed by histopathological biopsy.The liver stiffness measurement(LSM),blood routine laboratory indicators such as blood biochemistry.Use independent sample t-test for inter group comparison of counting data.Using receiver operating characteristic curves to analyze the diagnostic efficacy of liver hardness values and serological indicators on the degree of liver fibrosis in children with biliary atresia and cholestasis.Results The LSM and serum γ-glutamyl transferase levels in children with biliary atresia were higher than those in children with cholestatic liver disease,and the differences were statistically significant(P＜0.05).The receiver operating characteristic analysis showed that the area under the receiver operating characteristic was 0.849 and the cut off value was 8.91 kPa when LSM was used to diagnose biliary atresia and hepatic fibrosis before surgery,which was higher than the efficacy of serum γ-glutamyl transferase in diagnosing biliary atresia and hepatic fibrosis.The independent diagnostic efficacy of both before operation was less than LSM value and the efficacy of serum γ-glutamyl transferase index in distinguishing cholestatic liver disease and biliary atresia.Conclusion The diagnostic efficacy of transient elastography combined with serumγ-glutamyl transferase for liver fibrosis in children with biliary atresia is higher than that of transient elastography alone or serumγ-glutamyl transferase,providing a favorable basis for the differentiation and diagnosis of liver fibrosis in children with biliary atresia in clinical practice.