Correlation Between NLR and Short-Term Prognosis of Heart Transplantation
LI Haoqi
WANG Zhihua
HU Junlong
SUN Junjie
CHEN Zhigao
ZHANG Xiaoxue
LIU Qianjin
CHENG Zhaoyun
Abstract：Objective To evaluate the impact of preoperative neutrophil to lymphocyte ratio(NLR)on short-term prognosis in orthotopic heart transplantation(HTx).Methods A retrospective analysis was conducted on clinical data from 44 patients with end-stage heart failure who underwent orthotopic heart transplantation at Central China Fuwai Hospital of Zhengzhou University between April 2018 and March 2024.Preoperative baseline data,last absolute counts of neutrophils,lymphocytes,monocytes,platelets,surgical details,and postoperative follow-up data were collected.The receiver operating characteristic(ROC)curve was constructed to calculate the area under the curve(AUC),the Youden index was used to determine the NLR cutoff value,dividing patients into high NLR and low NLR groups,statistical analyses were performed on baseline data,perioperative data,and short-term prognosis.Results The cutoff value of NLR calculated by the ROC curve was 3.494.Compared with the low NLR group,the high NLR group had a longer postoperative length of stay in the intensive care unit,the difference was statistically significant(P＜0.05).The mechanical ventilation time in the high NLR group was longer than that in the low NLR group,the difference was statistically significant(P＜0.05).The 3-month postoperative mortality in the high NLR group was higher than that in the low NLR group,the difference was statistically significant(P＜0.05).The utilization rate of continuous renal replacement therapy(CRRT)in the high NLR group was higher than that in the low NLR group,the difference was statistically significant(P＜0.05).There were no statistically significant differences between the two groups in terms of gender,age,smoking history,hypertension history,preoperative serum creatinine,preoperative total bilirubin,preoperative use of intra-aortic balloon pump(IABP),and left ventricular ejection fraction(P＞0.05).Also,there were no significant differences in surgical data between the two groups(P＞0.05).Conclusion Preoperative high NLR is associated with early postoperative mortality and increased CRRT usage following heart transplantation,indicating its potential prognostic value.
Keywords：end-stage heart diseaseheart transplantationprognosisneutrophilslymphocyte
Publication Date：2025-03-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 986-990 )