Correlation of Serum H-FABP,ApoA Ⅰ,VE-Cad Levels with the Number of Coronary Artery Lesions and Prognosis in Patients with Acute Myocardial Infarction

ZHU Caihong; LI Chenchen

doi:10.3969/j.issn.1004-437X.2025.05.019

Abstract：Objective To investigate the correlation of serum heart-type fatty acid binding protein(H-FABP),apolipoprotein A Ⅰ(ApoA Ⅰ)and vascular endothelial cell cadherin(VE-Cad)with the number of coronary artery lesions and prognosis in patients with acute myocardial infarction(AMI).Methods A total of 96 patients with AMI treated in Zhengzhou Seventh People's Hospital from June 2022 to January 2024 were included in the study(observation group),and they were divided into single-vessel group(32 cases),double-vessel group(40 cases)and multi-vessel group(24 cases)according to the number of diseased vessels.Another 50 healthy middle-aged and elderly people were selected as the control group.The differences of serum H-FABP,ApoA Ⅰ and VE-Cad levels between the control group and the observation group were compared.The serum levels of H-FABP,ApoA Ⅰ and VE-Cad were compared among the single-vessel group,double-vessel group and multi-vessel group.Spearman rank correlation analysis was used to analyze the correlation between serum H-FABP,ApoA Ⅰ,VE-Cad levels and the number of coronary artery lesions.The levels of serum H-FABP,ApoA Ⅰ and VE-Cad in AMI patients with different prognosis were compared.Receiver operating characteristic(ROC)curve was used to analyze the clinical value of serum H-FABP,ApoA Ⅰ and VE-Cad levels in predicting the poor prognosis of AMI patients.Results Compared with the control group,the observation group had a higher serum level of H-FABP and lower levels of ApoA Ⅰ and VE-Cad(P＜0.05).There were significant differences in serum H-FABP,ApoA Ⅰ and VE-Cad levels among the three groups(P＜0.05).Spearman rank correlation analysis showed that serum H-FABP level was positively correlated with the number of coronary artery lesions(P＜0.05),and serum ApoA Ⅰ and VE-Cad levels were negatively correlated with the number of coronary artery lesions(P＜0.05).Compared with the good prognosis group,the poor prognosis group had a higher level of serum H-FABP and significantly lower levels of ApoA Ⅰ and VE-Cad(P＜0.05).ROC curve analysis showed that the best cut-off values of serum H-FABP,ApoA Ⅰ and VE-Cad levels for predicting poor prognosis of AMI patients were 34.90 μg·L-1,0.95 g·L-1 and 3.92 ng·L-1.The area under the curve was 0.974,0.968,0.964(P＜0.05).The sensitivity were 100.00％,92.59％,100.00％,and the specificity were 82.61％,86.96％,81.16％,respectively.Conclusion The levels of H-FABP in patients with AMI are higher,while the levels of ApoA Ⅰ and VE-Cad are lower.With the increase of the number of diseased branches,the levels of H-FABP in patients with AMI will further increase,while the levels of ApoA Ⅰ and VE-Cad will further decrease.The levels of H-FABP,ApoA Ⅰ and VE-Cad have certain value in predicting the poor prognosis of patients with AMI.