Expression of miR-124-3p,lncRNA-MALAT-1 in Acute Myeloid Leukemia and Its Correlation with Clinical Features,Chemotherapy Efficacy,Prognosis
ZHAO Dong
YANG Xiaoyu
Abstract：Objective To explore the expression level of long non-coding RNA(lncRNA)-metastasis associated lung adenocarcinoma transcript 1(MALAT-1),microRNA-124-3p(miR-124-3p)in acute myeloid leukemia and its correlation with clinical characteristics,chemotherapy efficacy and prognosis.Methods The study was conducted from January 2020 to December 2022.A total of 98 patients with acute myeloid leukemia were included in the study group,given standard chemotherapy regimen for treatment,and 98 healthy volunteers were selected as the control group to compare the levels of miR-124-3p and lncRNA-MALAT-1.The clinical data of the study group were collected,and the correlation of each index,chemotherapy efficacy and prognosis with miR-124-3p and lncRNA-MALAT-1 expression were explored.Results The miR-124-3p level in the study group was lower than that in the control group,the lncRNA-MALAT-1 level was higher than the control group(P＜0.05).There was no statistical difference in miR-124-3p,lncRNA-MALAT-1 levels between gender,age,platelet count,hemoglobin,extramedullary lesions,FAB classification(P＞0.05).In the study group,the miR-124-3p level of patients with white blood cell count ≥30 × 109 L-1 and bone marrow original cell ratio ≥70％was lower,the lncRNA-MALAT-1 level was higher(P＜0.05).Patients in the invalid group had lower miR-124-3p levels than those in the effective group,lncRNA-MALAT-1 level than the effective group(P＜0.05).Patients in the poor prognosis group had lower miR-124-3p levels than the good prognosis group,lncRNA-MALAT-1 levels were higher than those in the good prognosis group(P＜0.05).Conclusion The level of miR-124-3p in blood of patients with acute myeloid leukemia was decreased,and the level of lncRNA-MALAT-1 was increased.The expression levels of miR-124-3p and lncRNA-MALAT-1 are associated with the clinical characteristics,chemotherapy efficacy and prognosis of AML patients.
Keywords：acute myeloid leukemialong non-coding RNA-metastasis associated lung adenocarcinoma transcript 1micro RNA-124-3pclinical featureschemotherapyprognosis
Publication Date：2025-03-13
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 820-824 )