Diagnostic Value of Galectin-3 in Heart Failure in Ischemic Cardiomyopathy
ZHU Wanjie
ZHANG Haijiao
DONG Jing
ZHANG Juan
Abstract：Objective To study the difference of galectin-3(Gal-3)expression in ischemic cardiomyopathy(ICM)heart failure and non-ischemic cardiomyopathy(NICM)heart failure patients,and to study its correlation with cardiac function and evaluate its clinical value.Methods Patients with grade Ⅱ-Ⅳ heart failure with cardiac function admitted to the Second Affiliated Hospital of Zhengzhou University from January to October 2022 were selected and divided into ICM heart failure group(39 cases)and NICM heart failure group(36 cases).The corresponding control group(35 cases)was also selected.After admission,the expression level of Gal-3 in plasma was detected by enzyme-linked immunosorbent assay.The differences of Gal-3 and related indexes among all groups were compared,and the data were statistically analyzed.Results The difference of Gal-3 level among the three groups was statistically significant(P＜0.05),and the difference between any two groups was statistically significant(P＜0.05).In the ICM and NICM heart failure groups,there were statistically significant differences in Gal-3 in grade Ⅱ and Ⅲ heart function patients(P＜0.001),and the level of Gal-3 in grade Ⅲ was higher than that in grade Ⅱ.Gal-3 level was negatively correlated with left ventricular ejection fraction(LVEF)(r=-0.576,P＜0.001)and positively correlated with left ventricular end diastolic diameter(LVEDD)(r=0.494,P=0.001)in ICM group.The receiver operating characteristic(ROC)curve area under(AUC)of Gal-3 for diagnosis of heart failure was 0.851(95％CI:0.778-0.924,P＜0.001),the optimal threshold was 3.68 µg·L-,the sensitivity was 73.3％,and the specificity was 82.9％.The AUC of Gal-3 for ICM heart failure diagnosis was 0.898(95％CI:0.837-0.958,P＜0.001),the optimal threshold was 4.505 μg·L,the sensitivity was 74.4％,and the specificity was 93.0％.Conclusion Gal-3 has certain diagnostic value for patients with heart failure.The specificity value of Gal-3 in the diagnosis of ICM heart failure patients has further improved.There is a correlation between Gal-3 and cardiac function in patients with ICM heart failure,indicating that it may be related to myocardial remodeling.
Keywords：ischemic cardiomyopathyheart failuregalectin-3
Publication Date：2025-03-13
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 806-810 )