Expression of WWOX and WBP2 in Bladder Cancer and Its Clinical Prognostic Significance
LIU Taiyang
LI Jie
WEN Xiuhua
SHEN Yanbing
GUI Qi
Abstract：Objective To explore the expression and clinical prognostic significance of WW domain-containing oxidoreductase(WWOX)and WW domain-binding protein 2(WBP2)in bladder cancer.Methods A total of 112 patients with bladder cancer admitted to Zhumadian Central Hospital from December 2017 to December 2019 were selected,and the cancer tissue specimens of bladder cancer patients(bladder cancer group)and the corresponding paracancerous tissue specimens(paracancerous group)were collected.The WWOX and WBP2 in bladder cancer tissues and adjacent tissues were measured by immunohistochemistry.The relationship between the WWOX,WBP2 and the clinicopathological characteristics of bladder cancer cases was explored by x2 test.The factors affecting the prognosis of cases with bladder cancer were explored by multivariate Cox regression analysis.Results The positive rate of WBP2 in bladder cancer group was higher compared with adjacent group,and the positive rate of WWOX in bladder cancer group was lower compared with adjacent group(P＜0.05).The positive expression rate of WBP2 and negative expression rate of WWOX in bladder cancer patients with low differentiation,tumor diameter≥1 cm,TNM stage Ⅲ-Ⅳ,lymph node metastasis and vascular space invasion were higher than those in bladder cancer patients with medium/high differentiation,tumor diameter＜1 cm,TNM stage Ⅰ-Ⅱ,no lymph node metastasis and no vascular space invasion(P＜0.05).The 3-year survival rate of patients with negative WWOX expression was higher than patients with positive WWOX expression(P＜0.05).The 3-year survival rate of cases with positive WBP2 was lower compared with cases with negative WBP2(P＜0.05).Ⅲ-Ⅳ stage,lymph node metastasis,negative WWOX and positive WBP2 were risk factors for the prognosis of patients with bladder cancer(P＜0.05).Conclusion WWOX is mainly negative expression in bladder cancer tissues and WBP2 is mainly positive expression.Both of them are closely related to the clinicopathological characteristics of bladder cancer patients,and are expected to be used as a marker to evaluate the prognosis of bladder cancer.
Keywords：bladder cancercancer tissueWW domain-containing oxidoreductasesWW domain binding protein 2
Publication Date：2025-02-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 653-657 )