Application Value of Low-Dose Spiral CT Combined with Tumor Markers in the Screening of High-Risk Populations for Lung Cancer
WANG Biao
DONG Yafeng
MA Wen
BIAN Miao
Abstract：Objective To investigate the value of low-dose spiral computed tomography(LDCT)combined with serum tumor markers progastrin-releasing peptide(Pro-GRP),neuron-specific enolase(NSE),cyto-keratin 19 fragment antigen 21-1(CYFRA21-1),serum carcinoembryonic antigen(CEA)in early lung cancer screening.Methods A total of 146 suspected lung cancer cases undergoing LDCT scans at Henan Cancer Hospital from March 2021 to March 2023 were included.Based on pathological diagnosis results,they were divided into lung cancer group(114 cases)and benign lesion group(32 cases).The levels of serum tumor markers,CT imaging findings,and the accuracy of their combined use in early lung cancer diagnosis were compared and analyzed between the two groups.Results The accuracy,sensitivity,and specificity of LDCT in diagnosing lung cancer are 70.55％,69.35％,and 81.82％,respectively.The differences in imaging features such as nodule classification,lobulation,spiculation,and pleural indentation between lung cancer and benign lesions were statistically significant between the two groups(P＜0.05).The serum tumor marker levels in the lung cancer group were higher than those in the benign lesion group(P＜0.05).ROC curve analysis showed that the AUC of LDCT combined with serum tumor markers for the diagnosis of early lung cancer was 0.850,with sensitivity,specificity,and accuracy of 85.9％,81.25％,and 84.25％,respectively,all higher than the diagnosis of each indicator alone.Conclusion Low-dose spiral CT combined with serum tumor markers has high diagnostic value for early lung cancer.
Keywords：early lung cancerlow-dose spiral CTtumor markersdiagnostic value
Publication Date：2025-02-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 636-640 )