Effects of Electroencephalogram Biofeedback Combined with Lamotrigine on Sleep Electroencephalogram Activity in Chronic Schizophrenia

ZHANG Hui; KONG Weina; XUE Jinyan

doi:10.3969/j.issn.1004-437X.2025.04.011

Abstract：Objective The purpose of this study was to compare the effects of electroencephalogram biofeedback,lamotrigine and their combination therapy on sleep electroencephalogram activity in patients with chronic schizophrenia.Methods From January 2021 to January 2023,98 patients with chronic schizophrenia who were treated in the psychiatry department of the Kaifeng Fifth People's Hospital were selected and randomly divided into three groups:electroencephalogram Biofeedback group(33 cases),lamotrigine group(33 cases)and combination therapy group(32 cases).The electroencephalogram Biofeedback group received the specified electroencephalogram biofeedback training,the lamotrigine group received routine lamotrigine treatment,and the combination therapy group received both electroencephalogram biofeedback training and lamotrigine treatment.By comparing the brainwave status of three groups of patients(β,θ,SMR wave),neural function index level[neuron specific enolase(NSE)level,brain-derived neurotrophic factor(BDNF)and homocysteine(Hey)]and patients'sleep quality were evaluated.Results After intervention,the combined treatment group exhibited higher β waves and SMR waves compared to the electroencephalogram biofeedback group and the lamotrigine group,while θ waves were lower than in the electroencephalogram biofeedback group and the lamotrigine group.Additionally,the combined treatment group showed lower levels of Hey and NSE,higher levels of BDNF,and better sleep quality compared to the electroencephalogram biofeedback group and the lamotrigine group.All differences were statistically significant(P＜0.05).Conclusion Electroencephalogram Biofeedback combined with lamotrigine can significantly improve sleep electroencephalogram activity in patients with chronic schizophrenia.