Compatibility and Medication Rules of Poria Based on Association Rules

LI Fubo; WANG Kuipeng

doi:10.3969/j.issn.1004-437X.2025.04.003

Abstract：Objective To explore the compatibility rules of Poria formula preparations.Methods Using"Poria"as the keyword,extract the formulations containing Poria included in the 2020 edition of the Chinese Pharmacopoeia,and use Excel to calculate the frequency of relevant indicators.Using the Apriori association rule algorithm in IBM SPSS Modeler 18.0 to mine 181 medicinal formulations of Poria,commonly used for the treatment of lung,spleen,and heart diseases.In reproductive diseases,it was mainly used for the compatibility relationship of female reproductive products.Visualize the network diagram of high-frequency drug use data to display the correlation between drugs.Results The diseases in the category of Qi,blood and fluid were mainly used in the treatment of deficiency and labor.The diseases in the category of pediatrics were mainly used in the treatment of pediatric miscellaneous diseases.The diseases in the category of head,body and form were mainly used in the treatment of paralysis.The diseases in the category of externals were mainly used in the treatment of externally-induced seasonal diseases,and so on.The high-frequency Chinese medicines paired with Poria include licorice,atractylodes,Chenpi,Chinese angelica sinensis,prepared rehmannia root,etc.The analysis of the association rules of high-frequency Chinese medicines shows that the two-drug combinations with higher support were Poria-licorice,Poria-atractylodes,Poria-Chenpi,etc.The three-drug combinations of Poria-Atractylodes,Poria-Chenpi-Atractylodes,Poria-debark peony root-Chinese angelica,and Poria-licorice-Chenpi are most highly supported;and the four-drug combinations of Poria-debark peony root-Chinese angelica-atractylodes,Poria-Chuanxiong-prepared rehmannia root-Chinese angelica,Poria-debark peony root-prepared rehmannia root-Chinese angelica had the highest support.Conclusion Through the research on the pattern and application of the compounding of Poria formula preparations,the pattern of Poria compounding was revealed to provide a new model for the in-depth study of Poria.