Value of Color Doppler Ultrasound Blood Flow Parameters Combined with Serum STK1 Level in Differential Diagnosis of Thyroid Nodules

DENG Shumin; ZHU Haixia

doi:10.3969/j.issn.1004-437X.2025.03.018

Abstract：Objective To analyze the value of color Doppler ultrasound blood flow parameters[resistance index(RI),peak systolic velocity(PSV),end diastolic velocity(EDV),vascular flow index(VFI)levels]combined with serum thymidine kinase 1(STK1)level in the differential diagnosis of thyroid nodules.Methods From June 2021 to June 2023,100 patients with thyroid nodules in Xinyang Central Hospital were selected as the research objects,and they were divided into benign nodules group(76 cases)and malignant nodules group(24 cases)according to the pathological results.The distribution of ultrasonic characteristics,hemodynamic parameters and serum STK1 level were compared between the two groups,the levels of common clinical diagnostic indicators carcinoembryonic antigen(CEA),thyroglobulin antibody(TGAb)and thyroid peroxidase antibody(TPOAb)were compared,the correlation and diagnostic value for malignant thyroid nodules were analyzed.Results The hemodynamic parameters of PSV,VFI,EDV,RI and serum levels of STK1,CEA,TPO-Ab,TGAb in patients with benign nodules were lower than those in patients with malignant nodules,and the hemodynamic parameter of EDV in patients with benign thyroid nodules was higher than that in patients with malignant thyroid nodules(P＜0.05).Serum STK1 was positively correlated with CEA,TPO-Ab and TGAb(P＜0.05).The area under the curve(AUC)of color Doppler ultrasound blood flow parameters and serum STK1 level in the diagnosis of malignant thyroid nodules at admission was 0.778.Conclusion The combined detection of color Doppler ultrasound blood flow parameters and serum STK1 level at admission can improve the sensitivity of the disease,and the combined detection of the two has important clinical application value in differentiating benign and malignant thyroid nodules.