Analysis of the Distribution Characteristics and Drug Resistance of Streptococcus Pneumoniae in a Hospital in Luohe from 2019 to 2023

MENG Yanping; LI Ning; CHANG Junling; LIN Guangmin; CAO Xinghua

doi:10.3969/j.issn.1004-437X.2025.02.017

Abstract：Objective To analyze and understand the distribution and clinical drug resistance of Streptococcus pneumoniae in Luohe Central Hospital from 2019 to 2023,and to provide a basis for clinical medication.Methods Retrospective analysis of Streptococcus pneumoniae strains from Luohe Central Hospital from 2019 to 2023,using the French BioMérieux VITEK2 Compact automatic microbial identification and susceptibility analyzer to identify and analyze the drug sensitivity of the collected bacteria,while using E-test strips for verification.Results A total of 2 136 cases were collected,mainly sputum samples(97.2％).The department distribution is mainly pediatrics(90.2％),with children under 5 years old accounting for the most(85.3％),and the proportion of people aged 6-18 and adults was low but has an upward trend.December,January were the high incidence seasons for Streptococcus pneumoniae,with a higher infection rate in males than in females.In drug sensitivity experiments,the drug resistance rate of some drugs in the penicillin resistant Streptococcus pneumoniae(PRSP)group was higher than that in the penicillin sensitive Streptococcus pneumoniae(PSSP)group,and the detection rate of PSSP has an upward trend within 5 years.Erythromycin,tetracycline,and third-generation cephalosporin had serious resistance.The resistance rates of ceftriaxone,cefotaxime,levofloxacin,and moxifloxacin were low,with differences between the juvenile and adult groups.The detection rate of PSSP in blood isolates was 37.1％,and the detection rate of PSSP in sputum isolates was 9.9％.Conclusion The infection of Streptococcus pneumoniae in children under 5 years old in Luohe Central Hospital is more serious,and the degree of drug resistance varies with antibiotic treatment.Clinical physicians should use antibiotics reasonably to prevent further deterioration of drug resistance.