Prognostic Value of Postoperative Neutrophil to Lymphocyte Ratio in Patients with Locally Advanced Pancreatic Cancer After Nanoknife Ablation

WEI Guangkun; CHEN Yanjun; CHENG Bingbing; TONG Hao; CHEN Shengyang; HU Shuiquan

doi:10.3969/j.issn.1004-437X.2025.02.006

Abstract：Objective To investigate the prognostic significance of neutrophil to lymphocyte ratio(NLR)in patients with locally advanced pancreatic cancer after nanolithotomy.Methods From July 2015 to May 2020,the clinical data of 45 patients with locally advanced pancreatic cancer who met the inclusion criteria and were treated with nanoknives in the Fifth Affiliated Hospital of Zhengzhou University were retrospectively analyzed.According to the NLR value of postoperative peripheral venous blood,patients were divided into low NLR group(NLR≤4.8,22 cases)and high NLR group(NLR＞4.8,23 cases)with the median NLR as the critical value.X2 test was used to compare the difference between the two groups.Multivariate analysis of Cox proportional risk model was used to investigate whether NLR was an independent risk factor for the prognosis of patients with pancreatic cancer after nanoknife surgery.Results The median survival time was 294 days in the low NLR group and 126 days in the high NLR group(P＜0.001).The results of single factor analysis showed that tumor diameter(P＜0.001),carbohydrate antigen 19-9(CA1 9-9)(P＜0.001),tumor site(P=0.030),degree of differentiation(P=0.006),30 days after surgery NLR(P＜0.001)and TNM stage(P=0.016)were associated with survival after nanolithotomy for locally advanced pancreatic cancer.The results of multivariate analysis showed that tumor diameter,postoperative NLR and tumor marker CA19-9 were independent factors influencing pancreatic prognosis of locally advanced pancreatic cancer.Conclusion Postoperative high NLR has a certain predictive value for the survival of patients with locally advanced pancreatic cancer after nano-knife surgery.NLR is easy to test in clinical practice and can provide important prognostic information.