Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Non-spatial Attention Disorder After Stroke

WANG Guosheng; FANG Mingzhu; LIANG Yingzi; GUAN Chenxia; GUO Jun; LI Zhe

doi:10.3969/j.issn.1004-437X.2025.02.005

Abstract：Objective To explore the effect of high-frequency repetitive transcranial magnetic stimulation(rTMS)in the left dorsolateral prefrontal lobe(DLPFC)on attentional function and event-related potential P300 in patients with non-spatial attention disorders after stroke.Methods A randomized controlled experimental design was used to randomly assign 43 patients with post-stroke non-spatial attention disorder into observation group and control group.Patients in both groups received conventional rehabilitation and drug therapy,and the observation group received high-frequency rTMS therapy on the basis of conventional rehabilitation and drug therapy.Attention function was assessed by Montreal cognitive assessment(MoCA),digital span test(DST)and letter deletion test before treatment and 4 weeks after treatment.The improvement of the latency and amplitude of event-related potential P300 in the two groups was evaluated.Results After 4 weeks of treatment,the scores of MoCA,DST and letter deletion test in observation group and control group were higher than before treatment,and observation group was higher than control group(P＜0.05).The incubation period of P300 in both the observation group and the control group was shorter than before treatment,and the shortening range was greater in the observation group(P＜0.05).The amplitude of P300 in both the observation group and the control group was higher than before treatment,and the increase amplitude in the observation group was greater(P＜0.05).Conclusion High-frequency rTMS treatment can significantly improve the non-spatial attention disorder in patients with stroke,and P300 can be used as an indicator to evaluate the attention function and the effect of rTMS treatment.