Incidence of Hypophosphatemia After Continuous Blood Purification in Patients with Acute Kidney Injury and Its Impact on Prognosis
ZHANG Ying
WU Qiongjiao
CHANG Yuping
WEI Danhui
YUAN Huan
Abstract：Objective To observe the occurrence of hypophosphatemia in patients with acute kidney injury(AKI)after continuous blood purification(CBP),and analyze its impact on the prognosis.Methods A prospective study was conducted to select 82 patients with AKI who were admitted to all ICUs of Sanmenxia Central Hospital from June 2019 to June 2022 as the research objects.A general data questionnaire was designed and the patients were investigated and counted in detail at admission.Eighty-two patients with AKI were treated with CBP after admission,and the occurrence of hypophosphatemia within 48 hours after treatment was observed.All patients were followed up for 30 days,and were divided into dead group and survival group according to the prognosis of patients.The general data and blood phosphorus changes of patients with different prognosis were compared.The relationship between blood phosphorus level and prognosis was analyzed using point binary correlation,and the impact of blood phosphorus level on the prognosis of patients was analyzed using Cox regression.Results Forty-eight(58.54％)of 82 AKI patients developed hypophosphatemia within 48 hours after CBP treatment.There was no statistical significant difference in sex,age,body mass index,concomitant basic diseases,long-term drinking history,long-term smoking history,and acute renal injury stage between the death group and the survival group(P＞0.05).The acute physiology and chronic health evaluation(APACHE)Ⅱ score and the duration of CBP treatment in the death group were higher than those in the survival group,with a statistical significant difference(P＜0.05).The blood phosphorus level in the dead group was lower than that in the survival group at the end of treatment,with a statistical significant difference(P＜0.05).Point binary analysis showed that APACHE Ⅱ score and CBP treatment duration were positively correlated with poor prognosis of AKI patients(r＞0,P＜0.05).The serum phosphorus level was negatively correlated with the poor prognosis of AKI patients(r＜0,P＜0.05).Cox regression analysis showed that high expression of APACHE Ⅱ score and long duration of CBP treatment were risk factors for the prognosis of AKI patients(HR＞1,P＜0.05).High serum phosphorus level at the end of treatment was a protective factor for the prognosis of AKI patients(HR＜1,P＜0.05).Conclusion The incidence of hypophosphatemia in AKI patients during CBP treatment is high,and it will affect the prognosis of patients.
Keywords：acute kidney injurycontinuous blood purificationhypophosphatemiablood phosphorus levelprognosis
Publication Date：2025-01-14
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 88-91 )