Risk Factors for Recurrence After Minimally Invasive Resection in Patients with Stage Ⅰ A Non-small Cell Lung Cancer
LI Zhiwei
YANG Long
SONG Weikang
LU Huawei
LI Rongyao
Abstract：Objective To explore the risk factors for recurrence after minimally invasive resection in patients with stage Ⅰ A non-small cell lung cancer.Methods The clinical data of 186 patients with stage Ⅰ A non-small cell lung cancer admitted to Zhoukou Central Hospital from January 2019 to June 2020 were retrospectively analyzed.The selected patients were divided into the recurrence group(54 cases)and the non recurrence group(132 cases)according to whether there was recurrence during the follow-up period.The follow-up,recurrence status,and clinical data between two groups were compared,and the risk factors for recurrence in stage Ⅰ A non-small cell lung cancer patients after minimally invasive resection was analyzed by multivariate logistic regression analysis.Results All patients were followed up for 5-30 months after discharge,the rate of recurrence was 29.03％,including ipilateral lung recurrence(11.83％),ipilateral pleura recurrence(2.15％),mediastinal lymph node recurrence(8.06％),stump combined with tracheal recurrence(1.08％),and tracheal stump recurrence(5.91％).The proportion of patients with age≥60 years,lesion diameter≥3 cm,low differentiation,positive bronchial stump,the level of preoperative serum carcinoembryonic antigen(CEA)≥2.5 μg·L-1 and preoperative whole blood neutrophil to lymphocyte ratio(NLR)≥2.5 in the recurrence group were higher than those of the non-recurrence group(P＜0.05).The results of multivariate logistic regression analysis showed that lesion diameter≥3 cm,low differentiation,positive bronchial stump resection,the level of preoperative serum CEA≥2.5 μg·L-1,and the level of preoperative whole blood NLR≥2.5 were independent risk factors for recurrence in patients with stage Ⅰ A non-small cell lung cancer after minimally invasive resection(OR=2.455,3.364,2.155,3.397,1.545;P＜0.05).Conclusion Patients with stage Ⅰ A non-small cell lung cancer had a higher risk of recurrence after minimally invasive resection.Lesion diameter ≥3 cm,low differentiation,positive resection of bronchial stump,the level of preoperative serum CEA≥2.5 µg·L-1 and preoperative whole blood NLR≥2.5 were independent risk factors for recurrence in patients with stage Ⅰ A non-small cell lung cancer after minimally invasive resection.Clinical treatment and intervention measures could be given accordingly to reduce postoperative recurrence.
Keywords：non small cell lung cancerstage Ⅰ Arecurrencerisk factor
Publication Date：2025-01-14
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 65-68 )