Expression Level and Clinical Significance of Serum Galectin-3 in Patients with Oral Squamous Carcinoma

GU Dongkun; TANG Xiaoyu; NIU Qianyun; FANG Zheng

doi:10.3969/j.issn.1004-437X.2024.21.017

Abstract：Objective To investigate the expression level and clinical significance of serum galectin-3(Galectin-3)in patients with oral squamous carcinoma(OSCC).Methods A total of 80 patients with OSCC treated in Nanyang Stomatological Hospital from June 2020 to March 2023 were selected as OSCC group,and 80 healthy subjects in the same period were selected as control group.The level of galectin-3 was detected by double antibody sandwich enzyme-linked immunosorbent assay(ELSIA).The correlation between serum galectin-3 and clinicopathological parameters of OSCC patients was analyzed,and the serum galectin-3 levels of OSCC group and control group were compared,and the predictive value of serum galectin-3 to OSCC was evaluated by receiver operating characteristic(ROC)curve,and the risk factors of OSCC were discussed by multivariate logistic regression analysis.Results The level of serum galectin-3 in OSCC group was higher than that in control group(P＜0.05).The level of serum galectin-3 in OSCC patients with age＞60 years,smoking history,pathological differentiation(low differentiation+medium differentiation),tumor＞2 cm,TNM stage(stage Ⅲ+stage Ⅳ),lymph node metastasis was significantly higher than that in OSCC patients with age≤60 years,no smoking history,pathological differentiation(high differentiation),tumor ≤2 cm,TNM stage(stage Ⅰ+stage Ⅱ),without lymph node metastasis(P＜0.05).The ROC curve shows that serum Galectin-3 has high diagnostic value for OSCC.Multivariate logistic regression analysis showed that the high expression of serum galectin-3 was the risk factor of OSCC(P＜0.05).Conclusion Patients with OSCC have elevated serum Galectin-3 levels,and elevated serum Galectin-3 level is independent related factor for OSCC,which is expected to be used as biomarker for OSCC invasion and metastasis assessment.