Significance of Serum FOXO3a,NLRP3,sICAM-1 Levels in Patients with Coronary Heart Disease Complicated with Hyperuricemia

YAN Guowei; LIU Wen; JIA Qingxia

doi:10.3969/j.issn.1004-437X.2024.21.015

Abstract：Objective To explore the significance of changes in the levels of forkhead transcription factor O subfamily member 3 a(FOXO3a),NLR family pyrin domain containing 3(NLRP3)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with coronary heart disease complicated with hyperuricemia(HUA).Methods A total of 156 patients with coronary heart disease admitted to the First Affiliated Hospital of Henan University of Science and Technology from January 2021 to August 2022 were selected as research objects,and were divided into HUA group(62 cases)and UA normal group(94 cases)according to uric acid level.Compared the general clinical data and levels of FOXO3a,NLRP3,and sICAM-1 between two groups,and analyzed the differences between FOXO3a,NLRP3,and sICAM-1 levels and indicators with statistical differences in clinical data,as well as the correlation between UA levels,logistic regression analysis was used to analyze the risk factors of coronary heart disease combined with HUA.The diagnostic value of combined detection of FOXO3a,NLRP3,and sICAM-1 levels in coronary heart disease combined with HUA was analyzed using the receiver operating characteristic(ROC)curve.Results The levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in HUA group were higher than those in UA normal group(P＜0.05).The levels of FOXO3a,NLRP3,and sICAM-1 in the HUA group were higher than those in the UA normal group(P＜0.05).Correlation analysis found that the levels of FOXO3a,NLRP3,and sICAM-1 were positively correlated with the levels of TC,TG,LDL-C,and UA(P＜0.05).Logistic regression analysis found that levels of TC(＞5.04 mmol·L-1),TG(＞1.88 mmol·L-1),LDL-C(＞2.53 mmol·L-1),FOXO3a(＞4.65 μg·L-1),sICAM-1(＞195.73 μg·L-1),and NLRP3(＞1 322.12 ng·L-1)were risk factors for coronary heart disease patients with HUA(P＜0.05).ROC analysis showed that the area under the curve(AUC)of FOXO3a,sICAM-1 and NLRP3 in the combined diagnosis of coronary heart disease combined with HUA was 0.811,and the sensitivity and specificity were 95.16％and 67.02％,respectively,which was superior to the diagnosis of single index of each index and had high diagnostic efficacy(P＜0.05).Conclusion FOXO3a,sICAM-1 and NLRP3 are involved in the occurrence of coronary heart disease complicated with HUA,and have high efficacy in clinical diagnosis of coronary heart disease complicated with HUA.