Predictive Value of Serum Netrin-1 in the Early Deterioration of Neurological Function in Acute Cerebral Hemorrhage
REN Erpeng
WANG Jiangtao
BAI Yahui
Abstract：Objective To investigate the predictive value of serum nerve axon guidance factor-1(netrin-1)in the early deterioration of neurological function in acute cerebral hemorrhage(ACH).Methods A total of 80 patients with ACH who were admitted and diagnosed in Pingdingshan the Second People's Hospital from October 2019 to October 2020 were selected as the research objects.According to the progress of neurological deterioration,they were divided into deterioration group(27 cases)and non-deterioration group(53 cases).Enzyme-linked immunosorbent assay was used to detect the level of netrin-1 of the two groups.The receiver operating characteristic(ROC)curve was used to evaluate the value of serum netrin-1 in predicting the early neurological deterioration of ACH.At the same time,multivariate logistic regression was used to analyze the related factors of the early neurological deterioration of ACH.Results The bleeding volume,rupture of the ventricle,National Institute of Health stroke scale(NIHSS)score and serum netrin-1 levels in the deterioration group were higher than those in the non-deterioration group(P＜0.05).ROC curve analysis showed that the area under the curve(95％CI)of serum netrin-1 for predicting the deterioration of neurological function in the early stage of ACH was 0.843(0.732-0.941),and the cut-off value was 412.37 ng·L-1,the specificity was 74.28％,and the sensitivity was 84.69％.Multivariate logistic regression analysis showed that high-level netrin-1(OR=2.82,95％CI:1.43-5.57)was an influencing factor of early neurological deterioration in patients with ACH(P＜0.05).Conclusion Serum netrin-1 is elevated in patients with ACH,which can be used as one of the potential reference indexes to predict the early neurological deterioration of cerebral hemorrhage and provide a reference for early diagnosis and treatment.
Keywords：acute cerebral hemorrhagedeterioration of neurological functionnerve axon guidance factor-1predictive value
Publication Date：2024-11-15
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 3880-3883 )