Correlation Analysis of Serum Tenascin-C Level with Severity and Prognosis in Patients with Acute Cerebral Hemorrhage
ZHANG Jianhong
ZHOU Xiaoqin
ZHAO Xiuyun
YANG Yingying
XU Yanhe
Abstract：Objective To analyze the correlation between the level of serum tenascin-C and the severity and prognosis of acute cerebral hemorrhage(ACH).Methods A total of 186 patients with ACH admitted to the First Affiliated Hospital of Zhengzhou University from August 2020 to August 2022 were selected as the observation group,and 186 healthy subjects were selected as the control group during the same period.Serum tenascin-C levels in control group and observation group were detected by enzyme-linked immunosorbent assay on 1,3 and 7 days after admission.The degree of neurological impairment was assessed,and the patients were grouped according to cerebral hemorrhage volume and the score of the National Institutes of Health stroke scale(NIHSS),and the serum tenascin-C level of each group was compared at each time point.The improved Rankin scale was used to evaluate the prognosis of patients 3 months after discharge and they were divided into good prognosis group and poor prognosis group.Logistic regression analysis was used to systematically evaluate the prognostic risk factors of ACH patients.Results The serum level of tenascin-C in the observation group was higher than that in the control group(P＜0.05).On 1,3 and 7 days after admission,the level of tenascin-C in the massive cerebral hemorrhage group was higher than that in the moderate and the small hemorrhage group,and the moderate cerebral hemorrhage group was higher than that in the small hemorrhage group(P＜0.05).The level of tenascin-C in the severe group was higher than that in the moderate group and the mild group,and the moderate group was higher than that in the mild group(P＜0.05).NIHSS score,intracerebral hemorrhage volume and tenascin-C level in the poor prognosis group were higher than those in the good prognosis group(P＜0.05).ROC curve analysis showed that the cut-off point of serum tenascin-C was 81.50 μg·L-1,the area under the curve was 0.854,the sensitivity was 90.88％,and the specificity was 72.60％.Logistic regression analysis showed that NIHSS score,cerebral hemorrhage volume and tenascin-C level were all risk factors for poor prognosis in ACH patients(P＜0.05).Conclusion The level of tenascin-C in serum of ACH patients is significantly increased,and is proportional to the amount of cerebral hemorrhage and neurological impairment.Tenascin-C can not only be used as a key biological marker to evaluate the severity of ACH injury,but also can predict the treatment effect and survival rate of patients.
Keywords：acute cerebral hemorrhagetenascin-Cprognosiscorrelation
Publication Date：2024-11-15
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 3877-3880 )