Treatment Effect of Transcatheter Arterial Chemoembolization Combined with Microwave Ablation in Patients with Hepatocellular Carcinoma

QIN Chuntang; XUE Dan; CHEN Weibin; WU Baojiang; XU Dong; GUO Tianli; LÜ Chaoyang

doi:10.3969/j.issn.1004-437X.2024.20.017

Abstract：Objective To evaluate the efficacy of transcatheter arterial chemoembolization(TACE)combined with microwave ablation(MWA)in the treatment of hepatocellular carcinoma(HCC).Methods The clinical data of 80 patients with HCC in Jiaozuo Second People's Hospital from December 2020 to December 2023 were retrospectively collected and divided into two groups according to treatment schemes.Among them,40 patients who received TACE combined with MWA treatment were classified as TACE combined with MWA group,and 40 patients who received TACE treatment were classified as TACE group.The curative effects of the two groups were compared,as well as the levels of liver function[direct bilirubin(D-Bil),albumin,total bilirubin(T-Bil)]and tumor markers[α-L-Fucosidase(AFU),carcino embryonic antigen(CEA),alpha-fetoprotein(AFP)],angiogenic factor[vascular endothelial growth factor(VEGF),platelet-derived growth factor(PDGF)]before and 3 months after treatment,the incidence of adverse reactions was also compared between the two groups.Results The disease control rate in TACE combined with MWA group was 97.50％(39/40),which was higher than that in TACE group[80.00％(32/40)](P＜0.05).At 3 months after treatment,serum albumin levels of the two groups were higher than before treatment,while the levels of D-Bil and T-Bil were lower,compared with TACE group,serum albumin level in TACE combined with MWA group was higher,while the levels of D-Bil and T-Bil were lower(P＜0.05).The levels of serum AFU,CEA and AFP in the two groups after 3 months of treatment were lower than those before treatment,and the TACE combined with MWA group were lower than those in the TACE group(P＜0.05).After 3 months of treatment,the levels of serum PDGF and VEGF in the two groups were lower than those before treatment,and compared with TACE group,the levels of serum PDGF and VEGF in TACE combined with MWA group were lower(P＜0.05).There was no statistical difference in the incidence of adverse reactions such as loss of appetite,nausea and vomiting,hair loss,diarrhea between the two groups(P＞0.05).Conclusion TACE combined with MWA in the treatment of HCC patients can further improve the curative effect,improve liver function,reduce the levels of tumor markers,inhibit the production of angiogenic factors,and do not increase the adverse reactions.