Relationship Between Maternal Immune Diseases and Fetal Growth Restriction
LÜ Huijuan
YANG Junjuan
ZHOU Bin
LI Baoping
Abstract：Objective To explore the relationship between maternal immune diseases and fetal growth restriction(FGR),with a view to providing evidence for early clinical intervention in FGR and reducing adverse outcomes for both mothers and infants caused by FGR.Methods A prospective study was conducted to select 254 singleton small for gestational age infants(SGA)admitted to Women&Infants Hospital of Zhengzhou from January 2021 to July 2023 as the research subjects.They were divided into the FGR group(82 cases)and the SGA group(172 cases)according to whether they had FGR.Clinical data were collected for all cases,including maternal age,family genetic history,miscarriage history,maternal smoking,parity,parity,oligohydramnios,placental abnormalities,gestational hypertension,hypoproteinemia,pregnancy-related infections,positive anti-phospholipid antibodies(any one positive),immunoglobulin three items[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)],complement C3,C4,serum thyroid hormones[triiodothyronine(T3),thyroxine(T4),thyroid stimulating hormone(TSH)],prenatal ultrasound diagnostic parameters(fetal weight,abdominal circumference),and analyzed the relevant factors affecting SGA infants as FGR.The logistic regression model was used to analyze the predictive value of FGR.Results There were statistically significant differences in the two groups in terms of placental abnormalities,gestational hypertension,hypoproteinemia,positive antiphospholipid antibodies,serum IgA,IgG,IgM,complement C3,C4,T3,T4,TSH,fetal weight,and abdominal circumference(P＜0.05).Multivariate logistic regression analysis showed that placental abnormalities,hypoproteinemia,positive antiphospholipid antibodies,elevated levels of serum immunoglobulin,T3 and TSH were independent risk factors for FGR in SGA.Elevated levels of serum complement C3,C4 and T4 were protective factors for FGR in SGA(P＜0.05).Logistic regression model was used for data analysis,the predictive probability P of FGR in SGA was obtained.According to the predicted value and true value,a receiver operating characteristic curve was drawn,with an area under the curve of 0.917(95％CI:0.876-0.962).When log(P)＞2.85,the predictive sensitivity was 80.59％and the specificity was 93.16％.Conclusion Maternal immune diseases are closely related to FGR.Clinicians can assess the risk of FGR through early screening for maternal immune diseases,placental abnormalities,hypoproteinemia,antiphospholipid antibodies,immunoglobulin levels,complement C3,C4,and thyroid hormone levels.This can be used to differentiate between SGA and develop targeted intervention plans.
Keywords：fetal growth restrictionsmall for gestational agematernal immune diseasesinfluence factor
Publication Date：2024-10-31
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 3696-3700 )