Differential Diagnostic Value of Quantitative Parameters of Contrast-Enhanced Ultrasound Combined with Serum Tumor Markers for Subpleural Tuberculosis,Lung Cancer,and Subpleural Tuberculosis Combined with Lung Cancer
DUAN Lian
FENG Yanfen
GAO Yuan
Abstract：Objective To explore the value of combining quantitative parameters of contrast-enhanced ultrasound with serum tumor markers in distinguishing subpleural pulmonary tuberculosis,lung cancer,and subpleural pulmonary tuberculosis with lung cancer.Methods The clinical data from 142 suspected cases of subpleural pulmonary tuberculosis,lung cancer were retrospectively analyzed.All patients underwent quantitative contrast-enhanced ultrasound examination and serum tumor markers,including carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),and vascular endothelial growth factor(VEGF),were detected by enzyme-linked immunosorbent assay.The quantitative parameters of contrast-enhanced ultrasound in patients with different diseases,including acceleration time(AT),peak intensity(PI),time to peak(TTP),time ratio(TR),and serum tumor marker levels were compared among different disease.Receiver operating characteristic(ROC)curves were drawn to analyze the differential value of different methods for lung cancer.Results There were 63 cases of subpleural pulmonary tuberculosis,66 cases of subpleural lung cancer,and 13 cases of subpleural pulmonary tuberculosis combined with lung cancer.The AT and TTP of lung cancer were shorter than those of pulmonary tuberculosis combined with lung cancer or pulmonary tuberculosis(P＜0.05),and the AT and TTP of pulmonary tuberculosis combined with lung cancer were shorter than those of pulmonary tuberculosis(P＜0.05).The PI,serum levels of CEA,CA125,and VEGF in lung cancer were higher than those in pulmonary tuberculosis combined with lung cancer or pulmonary tuberculosis(P＜0.05),and the PI and serum levels of VEGF in pulmonary tuberculosis combined with lung cancer were higher than those in pulmonary tuberculosis(P＜0.05).The TR of lung cancer was lower than those of pulmonary tuberculosis combined with lung cancer or pulmonary tuberculosis(P＜0.05),and the TR of pulmonary tuberculosis combined with lung cancer was lower than that of pulmonary tuberculosis(P＜0.05).The sensitivity,specificity,and area under the curve(AUC)of contrast-enhanced ultrasound quantitative parameters combined with serum tumor markers in the differential diagnosis of lung cancer were 100.00％,90.48％,and 0.934(95％CI:0.880-0.969),respectively,and the sensitivity and AUC were higher than those of individual differential diagnosis(P＜0.05).Conclusion Compared with subpleural pulmonary tuberculosis,subpleural pulmonary tuberculosis with lung cancer has shortened AT and TTP,decreased TR,increased PI and serum CEA,CA125,and VEGF levels,and lung cancer has shorter AT and TTP,lower TR,and higher PI and VEGF levels.The combination of quantitative parameters of contrast-enhanced ultrasound and serum tumor markers can improve the reliability of the diagnosis of lung cancer.
Keywords：contrast-enhanced ultrasoundtumor markerssubpleural tuberculosislung cancer
Publication Date：2024-10-31
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 3674-3678 )