Bacterial Flora Distribution and Drug Resistance of Urinary Tract Fungal Infection in Elderly Patients

CAI Cunhui

doi:10.3969/j.issn.1004-437X.2024.20.006

Abstract：;Objective To analyze the bacterial flora distribution and drug resistance characteristics of elderly patients with urinary tract fungal infection,and to provide experience guidance for clinical rational drug use.Methods A total of 2 563 urine samples collected from 226 elderly patients with urinary system infection in the Department of Urology of Zhengzhou Traditional Chinese Medicine Bone Injury Hospital from December 2020 to December 2022 were analyzed.The urine samples were inoculated on culture medium for pathogen culture.The bacterial species were identified according to the color difference of the bacterial species and further analyzed by automatic bacterial culture identification instrument.The drug sensitivity test was carried out with French Mérieux drug sensitive reagent strips to analyze the bacterial flora distribution and drug resistance characteristics of urinary fungal infection in elderly patients.Results A total of 7 fungal strains(252 strains)were isolated from 2 563 urine samples,and the detection rate of fungi was 9.83％.Candida albicans,Candida tropicalis and Candida glabrata accounted for 47.62％,23.02％ and 11.90％,respectively.The results of drug sensitivity test showed that none of the 7 fungi were resistant to 5-fluorocytosine and amphotericin B.The resistance rates of Candida albicans,Candida tropicalis and Candida glabrata to itraconazole were the highest,16.67％,18.97％ and 26.67％,respectively.The drug resistance rates of fluconazole were 15.00％,13.79％ and 23.33％,respectively.In 226 elderly patients with urinary tract fungal infection,218 cases were cured,8 cases failed,the total cure rate was 96.46％.Conclusion Candida albicans,Candida tropicalis and Candida glabrata are the main urinary fungal infections in elderly patients in this hospital,and these fungi have shown varying degrees of resistance to itraconazole and fluconazole.In future clinical trials,antifungal drugs can be reasonably selected based on the results of drug sensitivity tests in elderly patients.