Evaluation of Sedimentation and C-Reactive Protein Level on the Efficacy and Prognosis of Ankylosing Spondylitis
LI Sujuan
WANG Xinyi
GAO Fei
MA Shufang
Abstract：Objective To explore the evaluation role of erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)levels in the efficacy and prognosis of ankylosing spondylitis(AS).Methods A total of 90 patients with AS admitted to the Henan Integrative Medicine Hospital from June 2020 to June 2022 were selected as research objects.Bath ankylosing spondylitis disease astivity index(BASMI)score was used to evaluate the improvement of symptoms of lumbar stiffness before treatment,and BASMI score was used as the basis.The patients were divided into outcome group and adverse group.Single factor and logistic regression equation were used to analyze the risk factors affecting the recovery of AS patients,and the relationship between the expression levels of serum ESR and CRP and the recovery of AS patients was clarified.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum ESR and CRP detection for recovery of AS patients.Results After treatment,BASMI score,serum ESR and CRP levels in 90 patients with AS were significantly decreased compared with those before treatment(P＜0.05).Age,simple pain questionnaire(MPQ)and disease activity score in 28 joints(DAS28)scores,serum rheumatoid factor(RF),chemerin,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),ESR,CRP,white blood cell count(WBC),platelet(PLT),blood uric acid(BUA),matrix metallo proteinase-3(MMP-3),matrix metallo proteinase-9(MMP-9),interleukin-17(IL-17),interleukin-4(IL-4),toll-like receptor-4(TLR-4),interferon gamma(IFN-γ),interleukin-1β(IL-1β),and alcohol consumption in the outcome group were all lower than those in the adverse group.The serum Treg level was higher than that of adverse group,the course of disease and morning stiffness time were shorter than those of adverse group(P＜0.05).logistic regression analysis showed that disease duration(length),DAS28 score(high),ESR(high),BUA(high),RF(high),CRP(high)were risk factors affecting the recovery of AS patients(P＜0.05).ROC curve analysis showed that serum ESR and CRP predicted the therapeutic effect area under the curve(AUC)of AS patients to be 0.724 and 0.697,respectively,and the combined test predicted the therapeutic effect AUC of AS patients to be 0.830,both higher than serum ESR and CRP alone.Conclusion The expression of ESR and CRP in the serum of AS patients is relatively high,and both of them are risk factors affecting the rehabilitation of AS patients.They can be used as objective and effective indicators to accurately predict the changes in the condition of AS patients,and the combined detection has higher application value.
Keywords：ankylosing spondylitismeridional streamer sequential burying methodpain in the backerythrocyte sedimentationC-reactive protein
Publication Date：2024-06-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 2192-2196 )