Effect of Intravenous Injection Combined with Joint Tranexamic Acid Infusion in Patients After Shoulder Arthroscopic Rotator Cuff Repair
XING Linqing
HU Mingxin
DONG Yonghao
WANG Yong
ZHANG Baolong
YOU Xiaoying
YIN Wanle
Abstract：Objective To explore the effect of intravenous injection combined with tranexamic acid infusion in patients after shoulder arthroscopic rotator cuff repair.Methods Clinical data were gathered on 84 patients who underwent shoulder arthroscopic rotator cuff repair at the hospital from February 2020 to November 2022.According to the intraoperative hemostasis intervention method,they were divided into an observation group(56 cases,intravenous injection combined with intra-articular infusion of tranexamic acid)and a control group(28 cases,intravenous injection of tranexamic acid).The levels of hemoglobin,surgical bleeding,surgical time,shoulder joint swelling,pain level,shoulder joint function,complications,interleukin-1 β(IL-1β),tumor necrosis factor-α(TNF-α)and matrix metalloproteinase-3(MMP-3)between two groups were compared.Results One day after surgery,the hemoglobin levels in both groups decreased,and the observation group was higher than the control group(P＜0.001).There was a statistically significant difference in the amount of surgical bleeding and surgical time between the two groups(P＜0.001).The inter group,time and interaction effects of shoulder joint circumference between the two groups were statistically significant(P＜0.05).On postoperative day 1 and 2,there was a statistically significant difference in pain scores between the two groups,and the observation group was lower than the control group(P＜0.05).The pain scores of both groups at 2 days postoperatively were lower than those at 1 day postoperatively(P＜0.001).One month after surgery,the shoulder joint function scores of both groups were higher than before surgery,and the observation group was higher than the control group(P＜0.001).After surgery,IL-1 β,TNF-α and MMP-3 levels decreased in both groups,and the observation group were lower than the control group(P＜0.001).Conclusion The application of intravenous injection combined with articular tranatemic acid in shoulder arthroscopic rotator cuff repair surgery can effectively play a hemostatic role,reduce inflammation,relieve patients'pain,and improve shoulder joint function,which is relatively safe.
Keywords：tranexamic acidshoulder arthroscoperotator cuff repair surgerystop bleedinginflammationpain
Publication Date：2024-06-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 2180-2184 )