Relationship Between NLR,PLR and Carotid Atherosclerosis in Elderly Patients with Type 2 Diabetes with Normal Lipids

LU Shanshan; CHEN Yujuan; QIAO Lei; YANG Zaigang

doi:10.3969/j.issn.1004-437X.2024.12.012

Abstract：Objective To investigate the relationship between neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR)and carotid atherosclerosis in elderly patients with type 2 diabetes mellitus(T2DM)with normal blood lipids.Methods A total of 246 patients with T2DM with normal blood lipid levels were selected from the First Affiliated Hospital of Zhengzhou University from January 2022 to July 2023.According to the presence or lack of atherosclerosis,the patients were divided into T2DM group(C-IMT＜1 mm,group A)with 120 cases and T2DM combined with carotid atherosclerosis group(C-IMT ≥1 mm,group B)with 126 cases.NLR,PLR,platelets,neutrophils,and lymphocytes were detected and compared between the two groups.The risk factors of carotid atherosclerosis in T2DM patients were investigated by using multivariate logistic model.The diagnostic value of NLR and PLR for carotid atherosclerosis in T2DM patients was reflected by receiver operating characteristic(ROC)curve.Results Compared with group A,the levels of NLR,PLR,platelets,neutrophils and leukocytes in group B were increased,and the differences were statistically significant(P＜0.01).The conclusion of multivariate logistic model showed that NLR and PLR were risk factors for carotid atherosclerosis in patients with T2DM.ROC curve analysis showed that NLR and PLR single or combined detection had high diagnostic value for carotid atherosclerosis in elderly patients with T2DM(P＜0.01),and the area under the curve(AUC)value and specificity were the highest when NLR and PLR were combined detection.Conclusion NLR and PLR are independent risk factors for carotid atherosclerosis in elderly patients with T2DM,and have diagnostic value for the occurrence of carotid atherosclerosis.