Meta-Analysis of Clinical Efficacy of Gubenkechuan Decoction in the Treatment of Chronic Airway Diseases
WANG Qimeng
CHEN Jing
WANG Hongmin
WANG Weiwei
Abstract：Objective To systematically evaluate the therapeutic efficacy of Gubenkechuan on patients with chronic airway diseases.Methods The computer system was used to search for clinical studies on the treatment of chronic airway diseases with Gubenkechuan from the CNKI,WanFang,Chinese biomedical literature database,Vip database,PubMed,Embase and Cochrane Library.The Cochrane risk assessment was used to evaluate the quality of the included studies,and then meta-analysis of the clinical efficacy indicators was performed using RevMan 5.4 software.Results A total of 15 randomized controlled trials with 1 516 patients were included.Meta-analysis showed that treatment with Gubenkechuan increased the overall efficacy of treatment in patients with chronic airway diseases compared to the control group(P＜0.01),and the results in the subgroups were consistent with those in patients with chronic airway diseases.Compared to the control group,the treatment with Gubenkechuan also improved lung function indexes,and reduced tumor necrosis factor-α level in patients with chronic airway diseases(P＜0.01).No serious adverse effects were reported in any of the included studies.Conclusion Gubenkechuan could increase treatment efficiency,improve lung function indexes,and reduce serum inflammatory factor levels in patients with chronic airway diseases,and has a good safety profile.
Keywords：Gubenkechuanchronic airway diseaserandomized controlled trialmeta-analysis
Publication Date：2024-06-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：9( 2127-2135 )