Efficacy of Folic Acid Combined with Vitamin B12 on Erectile Dysfunction Patients with Hyperhomocysteinemia
TANG Zhao
WU Chunlei
YU Qinnan
ZHU Feng
XUE Xiangdong
HE Jun
ZHANG Huiqing
Abstract：Objective To observe the efficacy of folic acid combined with vitamin B12 in the treatment of erectile dysfunction(ED)patients with hyperhomocysteinemia(HHcy).Methods A total of 61 patients with ED and HHcy in the First Affiliated Hospital of Xinxiang Medical University from June 2021 to August 2022 were selected,and divided into observation group and control group according to the patient's wishes.Finally the observation group included 37 cases and the control group included 22 cases.The observation group was given oral folic acid tablets and vitamin B12 tablets,the control group was not given drug intervention.The levels of plasma homocysteine(Hcy),vitamin B12 and folic acid were measured before and after 12 weeks of treatment,and the erectile function status was assessed using the international index of erectile function-5(IIEF-5).Results There was no statistically difference in plasma Hcy,folic acid,vitamin B12 levels and IIEF-5 scores in the control group before and after treatment(P＞0.05).After treatment,the plasma folic acid,vitamin B12 levels and IIEF-5 score in the observation group increased and were higher than those in the control group(P＜0.01),while the plasma Hcy level decreased and was lower than that in the control group(P＜0.01).Conclusion Folic acid combined with vitamin B12 can reduce plasma Hcy levels and improve erectile function in ED patients with HHcy.
Keywords：erectile dysfunctionhyperhomocysteinemiafolic acidvitamin B12
Publication Date：2024-06-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 2113-2116 )