Application Effect of Remazolam Combined with Ropivacaine in Replantation of Severed Finger

QI Wenyong; DANG You; WANG Puyu; WU Zhaosen

doi:10.3969/j.issn.1004-437X.2024.10.013

Abstract：Objective To investigate the effect of remazolam combined with ropivacaine in replantation of severed finger.Methods A total of 159 patients who underwent severed finger replantation in the hospital from October 2021 to April 2023 were retrospectively selected and divided into the reference group(79 cases)and the study group(80 cases)according to anesthesia protocols.Ropivacaine anesthesia was included in the reference group,and remazolam combined with ropivacaine anesthesia was included in the study group.The hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP)]and sedation effect[modified vigilance/sedation scale(MOAA/S)score,bispectral index(BIS)]of the two groups were compared before surgery(T0),at the beginning of surgery(T,),1 hour after surgery(T2),and at the end of surgery(T3).The levels of oxidative stress index[serum superoxide dismutase(SOD)and malondialdehyde(MDA)]and the occurrence of adverse reactions were compared between the two groups before and 24 hours after operation.Results The intergroup,time and interaction effects of MAP,HR,MOAA/S and BIS value of two groups were statistically significant(P＜0.05).The SOD level of the study group was higher than that of the reference group,and the MDA level was lower than that of the reference group(P＜0.05).The total incidence of adverse reactions in the study group was 5.00％(4/80),which was not statistically significant compared with 7.59％(6/79)in the reference group(P＞0.05).Conclusion Remazolam combined with ropivacaine can effectively improve the quality of anesthesia,stabilize the hemodynamic level of patients,reduce oxidative stress damage,and is safe and reliable.