Correlation of HIF-1α,ANGPTL2,SDF-1 and Prognosis of Large Cerebral Infarction After Decompressive Craniotomy During Perioperative Period
GUO Rui
CHENG Huimin
SHI Lijun
LING Xiaozheng
Abstract：Objective To investigate the association of hypoxia-inducing factor 1α(HIF-1α),angiopoietin like protein 2(ANGPTL2),stromal cell derived factor 1(SDF-1)with the outcome of large hemispheeric infarction(LHI)after decompressive craniotomy during perioperative period.Methods A total of 158 patients with LHI who underwent decompressive craniotomy in the hospital from June 2020 to December 2022 were selected and divided into observation group(71 cases,＞20 points)and control group(87 cases,5-20 points)according to the National Institutes of Health stroke scale(NIHSS)score at admission.According to the modified Rankin scale(mRS)score 90 days after surgery,they were divided into poor group(64 cases,＞2 points)and good group(94 cases,≤ 2 points).The serum HIF-1α,ANGPTL2 and SDF-1 levels of the two groups were compared before surgery,and the correlation between the serum HIF-1α,ANGPTL2 and SDF-1 levels and NIHSS score was analyzed.The serum HIF-1α,ANGPTL2 and SDF-1 levels of the two subgroups were compared before surgery and 7 and 14 days after surgery.The influencing factors and predictive value of the outcomes of patients with LHI after decompressive craniectomy was analyzed.Results The serum levels of HIF-1α,ANGPTL2 and SDF-1 in the observation group were higher than those in the control group before surgery(P＜0.05).Serum HIF-1α,ANGPTL2 and SDF-1 levels were positively correlated with NIHSS score before surgery(P＜0.05).Compared with the good group,the serum levels of HIF-1α,ANGPTL2 and SDF-1 in the poor group were higher at 7 and 14 days after surgery(P＜0.05).The increase of serum HIF-1α,ANGPTL2 and SDF-1 levels at 7 and 14 days after surgery were risk factors for poor prognosis(P＜0.05).The combined prediction of serum HIF-1α,ANGPTL2 and SDF-1 levels was higher than that of single prediction of each index(P＜0.05).Conclusion The up-regulated expression of HIF-1α,ANGPTL2 and SDF-1 in serum is not only involved in the pathogenesis of LHI,but also closely related to the severity and prognosis of patients.Early detection is expected to be an important biochemical indicator to assist the diagnosis and prognosis of LHI.
Keywords：massive cerebral infarctiondecompressive craniectomyhypoxia inducible factor-1angiopoietin like protein 2stromal cell-derived factor-1
Publication Date：2024-02-29
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 637-640 )