Study and Evaluation on the Medicinal Value of Fiber-Like Substances of Spatholobus Suberectus

WU Guoxue; WU Tiankun; LI Xiaoxia; YANG Shuting; LIU Dong; DONG Jing; ZHANG Sisen; HAO Yibin; WANG Yishuo

doi:10.3969/j.issn.1004-437X.2024.04.003

Abstract：Objective To study whether the fiber-like substances that has not passed through the sieve after crushing the pieces of spatholobus suberectus has recycling value.Methods The samples of spatholobus suberectus were crushed and sieved into fine powder and fiber-like substances.The fine powder and fiber-like substances with different pore sizes were sieved by different pharmacopoeias respectively.After numbering,the extracts were extracted by ultrasonic extraction with 50％methanol.High performance liquid chromatography(HPLC)was used to determine the content of catechins in the obtained samples,and to determine the recycling value of fiber-like substances in spatholobus suberectus.The chromatographic conditions were Agilent C18 chromatographic column(4.6 mm × 100 mm,2.6 μm),the mobile phase was acetonitrile(A)-0.2％phosphoric acid aqueous solution,isocratic elution,volume ratio of 10∶90,the flow rate of 1.3 mL·min-1,and the detection wavelength of 278 nm.Results Spatholobus suberectus contained a lot of fiber-like substances,accounting for about 15％of the total weight of the medicinal material.The content of fiber-like substance extracts was＞8％,but compared with the powder passed through No.6 sieve,the content was lower.The catechin content in the fiber-like substance was less,about half of that in the powder.Conclusion The crushing and sieving process of fiber-like substances in spatholobus suberectus is relatively cumbersome,which affects the appearance of the dosage form and the patient's oral sensation during the preparation process.It can be directly discarded in clinical use to save time and production cost.