Predictive Value of Serum Hepcidin and Ferritin on Brain Edema in Patients with Brain Injury After Decompressive Craniectomy

XU Wenzhong

doi:10.3969/j.issn.1004-437X.2023.24.020

Abstract：Objective To analyze the relationship between serum hepcidin(Hepc),serum ferritin(SF)and brain edema after decompressive craniectomy in patients with brain injury,and explore its predictive value for brain edema.Methods From June 2020 to June 2022,118 patients with brain injury who underwent decompressive craniectomy in the Department of Neurosurgery of the Second Affiliated Hospital of Henan University of Science and Technology were selected to observe the occurrence of brain edema within 7 days after surgery.According to the occurrence of brain edema,the patients were divided into occurrence group and non-occurrence group.The general data collection table was designed,the clinical data and laboratory indexes of the patients were filled in and recorded,and the preoperative Hepc and SF levels were detected.The relationship between the levels of Hepc and SF and the occurrence of postoperative cerebral edema were analyzed,and the receiver operating characteristic(ROC)curve was drawn to explore the predictive effect of serum Hepc and SF levels on the occurrence of cerebral edema after decompressive craniectomy in patients with craniocerebral injury.Results Within 7 days after decompressive craniectomy,the incidence of brain edema in 118 patients with brain injury was 28.81％,and the rate of non-occurrence was 71.19％.There were statistical differences in cerebral hemorrhage volume and fibrinogen(Fib)level between the two groups(P＜0.05).There was no statistical difference between the two groups in other data(P＞0.05).The levels of serum Hepc and SF in the occurrence group were higher than those in the non-occurrence group(P＜0.05).Correlation analysis showed that serum Hepc and SF levels were positively correlated with postoperative cerebral edema(r＞0,P＜0.05).The ROC curve was drawn,and the results showed that the area under the curve(AUC)of serum Hepc and SF levels alone and in combination to predict brain edema after decompressive craniectomy in patients with brain injury were more than 0.7,which had certain value,and the combined prediction value of the two was higher.Conclusion Serum Hepc and SF levels have important predictive value in the occurrence of brain edema in patients with brain injury after decompressive craniectomy.