Diagnosis Value of FibroScan Combined GPC 3 and AFP Test for the Liver Fibrosis

WU Fengli; HOU Yuge

doi:10.3969/j.issn.1004-437X.2023.24.018

Abstract：Objective To study the diagnosis value of FibroScan combined glypican-3(GPC3)and alpha fetoprotein(AFP)in the diagnosis of liver fibrosis.Methods A total of 96 patients with chronic hepatitis B who were admitted to the hospital from January 2018 to December 2022 were selected as the research subjects.Among them,31 patients without fibrosis in S0 stage were classified as group A,35 patients with mild liver fibrosis in stages S1 to S2 were classified as group B,30 patients with moderate and severe liver fibrosis in stages S3 to S4 were classified as group C.The liver function related indicators,FibroScan,GPC3 and AFP indicators levels were compared among groups,the correlation of FibroScan,GPC3 and AFP indicators and liver function related indicators was analyzed,and the diagnostic value of the three indicators on liver fibrosis was analyzed.Results The glutamic-oxaloacetic transaminase(GOT),glutamic-pyruvic transaminase(GPT),hyaluronic acid(HA),laminin(LN),procollagen Ⅲ N-terminal peptide(PⅢNP),tpye Ⅳ collagen(Ⅳ-C),FibroScan,GPC3 and AFP levels in group B and group C were higher compared with group A,and those in group C were higher compared with group B(P＜0.05).Pearson analysis found that FibroScan,GPC3 and AFP were positively correlated with liver function related indicators respectively(P＜0.05).The combination of FibroScan,GPC3 and AFP had the highest diagnostic value for liver fibrosis,the area under the curve was 0.905,which was greater than each indicator detected separately(0.751,0.633,0.842,respectively).Conclusion FibroScan,GPC3 and AFP levels in patients with high degree of liver fibrosis also increase,and the combine detection of the three has diagnostic value for liver fibrosis,which is worth promoting and applying as a monitoring target in clinical practice.