Relationship Between Peripheral Blood HMGB1,IL-17 and Acute Heart Failure Combined with Upper Respiratory Tract Infection
XIA Zhenhua
TENG Wei
XUE Yongliang
Abstract：Objective To explore the relationship between peripheral blood high mobility group box 1(HMGB1),interleukin-17(IL-17)and acute heart failure(AHF)combined with upper respiratory tract infection.Methods A total of 80 patients with AHF and upper respiratory tract infection treated in the First Affiliated Hospital of Henan University were enrolled as infection group between March 2020 and July 2022,while 45 AHF patients without upper respiratory tract infection were enrolled as non-infection group.The peripheral blood HMGB1,IL-17,brain natriuretic peptide(BNP),myocardial enzymes[creatine kinase-MB(CK-MB),lactate dehydrogenase(LDH),creatine kinase(CK)]and ultrasonic cardiogram indexes were compared between the two groups.The relationship between HMGB1,IL-17 and BNP,myocardial enzymes,ultrasonic cardiogram indexes was analyzed by Pearson correlation analysis.According to disease outcomes within 28 days,patients in infection group were divided into poor prognosis group(n =54)and good prognosis group(n =26),and levels of HMGB1 and IL-17 between the two groups were compared.The relationship between HMGB1,IL-17 and disease outcomes was explored.Results The levels of peripheral blood HMGB1,IL-17,BNP,LDH,CK and CK-MB in infection group were higher than those in non-infection group(P<0.05).The levels of LAD and LVEDD in infection group were higher than those in non-infection group(P<0.05),while LVEF was lower than that in non-infection group(P<0.05).The levels of peripheral blood HMGB1 and IL-17 were positively correlated with BNP,LDH,CK,CK-MB,LAD and LVEDD levels(P<0.05),while negatively correlated with LVEF(P<0.05).The levels of peripheral blood HMGB1 and IL-17 in good prognosis group were lower than those in poor prognosis group,and proportion of cases with cardiac function grading at gradeⅡwas higher than that in poor prognosis group(P<0.05).Receiver operating characteristic(ROC)curve analysis showed that area under the curve(AUC)of HMGB1 combined with IL-17 for predicting poor prognosis was 0.876,greater than that of HMGB1 and IL-17 alone(0.827,0.801).Conclusion The levels of peripheral blood HMGB1 and IL-17 are correlated with upper respiratory tract infection in AHF,and combined detection of the two indexes has higher prognostic value.
Keywords：acute heart failureupperrespiratory tract infectionhigh mobility group box1interleukin-17disease outcome
Publication Date：2023-12-15
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 4298-4301 )