Relationship Between the Dynamic Changes of Serum Hcy and BNP and Early Postoperative Cognitive Dysfunction in Patients with Intracranial Aneurysmal Subarachnoid Hemorrhage
XU Wenzhong
Abstract：Objective To study the relationship between the dynamic changes of serum homocysteine(Hcy)and brain natriuretic peptide(BNP)and the early postoperative cognitive dysfunction in patients with intracranial aneurysmal subarachnoid hemorrhage.Methods A total of 98 patients with intracranial aneurysmal subarachnoid hemorrhage were selected from the Second Affiliated Hospital of Henan University of Science and Technology from January 2021 to October 2022.All patients received interventional endovascular embolization of aneurysms after clear diagnosis and exclusion of surgical contraindications.The general data of all patients,such as previous smoking history,gender,previous surgical history,age,time from onset to admission,weight,family genetic history,as well as Hunt-Hess grade,operation time,aneurysm diameter,aneurysm location and other clinical data were collected.The level of serum Hcy was measured by high performance liquid chromatography before operation,1 day,3 days,5 days and 7 days after operation,and the level of serum BNP was measured by radioimmunoassay.At the 14th day after operation,the cognitive function of patients was assessed by the Montreal cognitive assessment scale(MoCA),and they were divided into normal cognitive function group and cognitive dysfunction group according to the MoCA score.The relationship between the dynamic changes of serum Hcy and BNP and the early postoperative cognitive dysfunction in patients with intracranial aneurysmal subarachnoid hemorrhage was analyzed by point binary correlation.Results At 14 days after operation,56 of 98 patients with intracranial aneurysmal subarachnoid hemorrhage had cognitive impairment,accounting for 57.14％.The diameter of aneurysm in cognitive dysfunction group was larger than that in normal cognitive function group,with a statistical significant difference(P<0.05).There was no statistical significant difference between the two groups in terms of the time from onset to admission,family genetic history,Hunt-Hess grade,operation time,age and sex(P>0.05).The serum Hcy and BNP levels of patients in the two groups showed a downward trend before operation,1 day after operation,3 days after operation,5 days after operation and 7 days after operation,and the serum Hcy and BNP levels in the cognitive dysfunction group were higher than those in the normal cognitive function group at each time point,with a statistical significant difference(P<0.05).Point two column correlation analysis showed that the dynamic changes of serum Hcy and BNP were positively correlated with early postoperative cognitive dysfunction in patients with intracranial aneurysmal subarachnoid hemorrhage(r>0,P<0.05).Conclusion The dynamic changes of serum Hcy and BNP are related to the early postoperative cognitive dysfunction in patients with intracranial aneurysmal subarachnoid hemorrhage.The higher the serum Hcy and BNP levels,the greater the possibility of early postoperative cognitive dysfunction.
Keywords：aneurysmal subarachnoid hemorrhagecognitive functionserum homocysteinebrain natriuretic peptide
Publication Date：2023-12-15
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 4285-4289 )