Changes in Egr3,sRAGE,and Ascending Aortic Elastic Function in Coronary Heart Disease and Their Relationship with Lesion Severity
WANG Jianfa
XIE Na
Abstract：Objective To explore the changes of early growth response factor 3(Egr3),soluble glycation end product receptor(sRAGE),and ascending aortic elastic function in coronary heart disease and their relationship with the severity of the disease.Methods A total of 100 patients with coronary heart disease who were treated in the Third Affiliated Hospital of Xinxiang Medical College from January 2020 to May 2023 were selected as the observation group,including 60 patients with coronary syndrome and 40 patients with stable angina.A total of 100 healthy volunteers were selected as the control group.The levels of Egr3 and sRAGE in peripheral blood of the observation group and the control group were detected,and the differences in ascending aortic parameters among patients with different disease types and stenosis degrees in the observation group were analyzed.Results The peripheral blood Egr3 of the observation group was higher than that of the control group,while the sRAGE was lower than that of the control group(P＜0.05).The Egr3 of patients with coronary syndrome in the observation group was higher than that of patients with stable angina,while the sRAGE was lower than that of patients with stable angina(P＜0.05).The Egr3 of severe stenosis patients in the observation group was higher than that of mild and moderate stenosis patients,while the sRAGE was lower than that of mild and moderate stenosis patients(P＜0.05).The active stiffness index of patients with coronary syndrome in the observation group was higher than that of stable angina pectoris,while the ascending aortic dilation and anterior wall S-wave velocity were lower than stable angina patients(P＜0.05).The active stiffness index of moderate and severe stenosis patients in the observation group was higher than that of mild stenosis patients(P＜0.05).The dilation of the ascending aorta in patients with moderate and severe stenosis in the observation group was lower than mild stenosis patients(P＜0.05).The S-wave velocity of the anterior wall in patients with severe stenosis in the observation group was lower than mild and moderate stenosis patients(P＜0.05).Peripheral blood Egr3 was positively correlated with Gensini,while sRAGE and anterior wall S-wave velocity were negatively correlated with Gensini(P＜0.05).Conclusion The peripheral blood Egr3 and sRAGE levels are increased in patients with coronary heart disease,among which Egr3,sRAGE and ascending aortic elastic parameters are related to disease type and degree of stenosis.Egr3,sRAGE and front wall S-wave velocity are correlated with Gensini.
Keywords：early growth response factor 3soluble glycation end product receptorsascending aortaelastic functioncoronary heart disease
Publication Date：2023-12-15
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：6( 4280-4285 )