Risk Stratification and Prognostic Value of 24 Hours Holter Electrocardiogram Parameters in Patients with Malignant Ventricular Arrhythmias
ZHANG Weiqing
JIA Yaoqin
SHI Junshi
DING Huan
Abstract：Objective To investigate the risk stratification and prognostic value of 24 hours holter electrocardiogram parameters in patients with malignant ventricular arrhythmia(MVA).Methods A total of 89 MVA patients admitted to Henan Second Provincial People's Hospital from January 2021 to January 2023 were selected as the study group,and 89 healthy subjects in the same period were included as the control group in a 1∶1 ratio.The 24 hours holter electrocardiogram parameters of the two groups were analyzed by Spearman and the relationship between the 24 hours holter electrocardiogram parameters and risk stratification was analyzed.The study group was divided into survival subgroup and death subgroup according to the survival status after 4 weeks of amiodarone treatment.The 24 hours holter electrocardiogram parameters and 12-lead synchronous electrocardiogram parameters of the two groups were compared.Receiver operating characteristic(ROC)curve and area under curve(AUC)were plotted to analyze the prognostic value of 24 hours holter electrocardiogram in predicting MVA.Results(1)Standard deviation of R-R interval within 24 hours(SDNN),mean standard deviation of R-R interval per 5 min segment within 24 hours(SDANN),composition ratio of R-R interval difference between adjacent normal cardiac cycles≥50 ms(PNN50),24 hours QT interval variability(24 h-QTV)in the study group were lower than those in the control group,and gradeⅤ＜ⅣB＜ⅣA(P＜0.05).(2)SDNN,SDANN,PNN50,24 h-QTV were negatively correlated with risk stratification in study group(P＜0.05).(3)There were significant differences in SDNN,SDANN,PNN50,24 h-QTV,T peak-T end(Tp-Te),T peak-T end/QT interval(Tp-Te/QT),corrected T peak-T end(Tp-Tec)between the death subgroup and the survival subgroup after 2 weeks of treatment(P＜0.05).(4)After 2 weeks of treatment,SDNN,SDANN,PNN50 and 24 h-QTV combined prognostic value of MVA was better than that of Tp-Te,Tp-Tec and TP-Te/QT combined prognostic value.Conclusion SDNN,SDANN,PNN50,24 h-QTV in MVA patients are negatively correlated with risk stratification.Combined detection is helpful to improve prognostic value,guide clinical diagnosis and treatment,and promote good outcome of the disease.
Keywords：malignant ventricular arrhythmia24 hours holter electrocardiogramrisk stratificationprognosiscorrelation
Publication Date：2023-12-15
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 4276-4280 )