Effect of Intensity Modulated Radiotherapy Combined with Immunotherapy on Patients with Esophageal Squamous Cell Carcinoma
YANG Yanling
ZHANG Wanli
CHEN Yanan
SHEN Jing
Abstract：Objective To investigate the clinical efficacy of intensity-modulated radiotherapy combined with dendritic cell-cytokine-induced killer cells(DC-CIK)for esophageal squamous cell carcinoma(ESCC),and to analyze its effects on tumor markers,quality of life and immune function in patients.Methods A total of 205 patients with ESCC admitted to Anyang Cancer Hospital from April 2019 to June 2022 were selected for the study,and were divided into single group(98 cases)and combined group(107 cases)according to their treatment willingness.The single group was treated with intensity-modulated radiotherapy and the combined group was treated with intensity-modulated radiotherapy combined with DC-CIK.The clinical efficacy,toxic side effects and quality of life scores(EORTC QLQ-OES18)of the two groups were compared.The levels of tumor markers[carcinoembryonic antigen(CEA),cytokeratin 19 fragment antigen 21-1(CYFRA21-1),squamous epithelial cell carcinoma antigen(SCCA)],immune function(CD3+,CD4+,NK cells),vascular growth factors[vascular endothelial growth factor(VEGF),epidermal growth factor receptor(EGFR),transforming growth factor-β,(TGF-β1)]and expression of microRNA-137(miR-137)and microRNA-155(miR-155)were compared before and after treatment in both groups.Results The objective slow release rate in the combined group(49.53％)was higher than the single group(25.51％)(P＜0.05).The serum CEA,CYFRA21-1,SCCA,VEGF,EGFR,TGF-β1 levels were lower in the combined group than in the single group after treatment,and miR-137,miR-155 expression and EORTC QLQ-OES18 scores were lower than in the single group(P＜0.05).The CD3+,CD4+,and NK cells were higher in the combined group than in the single group after treatment(P＜0.05).The difference in the incidence of toxic side effects in the combined group compared with the single group was not statistically significant(P＞0.05).Conclusion The combination of intensity modulated radiation therapy and DC-CIK has a definite effect on ESCC,which can reduce the expression level of tumor markers in patients,inhibit tumor vascular growth,improve immune function,improve quality of life,and has certain safety.
Keywords：esophageal squamous cell carcinomaintensity modulated radiation therapydendritic cell cytokine induced killer cellstumor markersquality of life
Publication Date：2023-11-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 4103-4107 )