Effect of Dynamic Conformal Arc Radiation Therapy on Advanced Non-small Cell Lung Cancer
KANG Chongzhao
WANG Xiaohong
WANG Pei
HAN Zhenkun
WANG Wenguang
Abstract：Objective To investigate the effect of dynamic conformal arc therapy in treating advanced non-small cell lung cancer(NSCLC)and the influence on tumor markers and 3-year prognosis.Methods A total of 103 patients with advanced NSCLC who were admitted to the First Affiliated Hospital of Henan University of Science and Technology from June 2017 to December 2019 were divided into the study group(53 cases)and the control group(50 cases).Both groups underwent cisplatin combined with gemcitabine chemotherapy.On this basis,the study group underwent dynamic conformal arc therapy.Short-term efficacy,tumor markers and adverse reactions were compared between groups.The prognosis during 3 years of follow-up was evaluated.Results The objective response rate of the study group(50.94％)was higher than that of the control group(30.00％)(P＜0.05).The disease control rate in the study group(83.02％)was higher than that in the control group(62.00％)(P＜0.05).After treatment,serum carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC-Ag),cytokeratin 19 fragment(CYFRA21-1),tissue polypeptide antigen(TPA)and cytoplasmic thymidine kinase 1(TK1)in the study group were lower than those in the control group(P＜0.05).There was no statistically difference in the incidence of bone marrow suppression,nausea and vomiting,skin itching,eczema,blisters,radiation pneumonia,and radiation esophagitis between the two groups(P＞0.05).The survival rates of study groups 1,2 and 3 years were higher than those of the control group(P＜0.05).The overall survival period of the study group was longer than that of the control group(P＜0.05).Conclusion Dynamic conformal arc radiotherapy for advanced NSCLC can reduce tumor markers,control tumor progression,improve short-term efficacy,improve long-term prognosis,and prolong survival.
Keywords：dynamic conformal arc therapynon-small cell lung canceradvanced lung cancertumor markerprognosis
Publication Date：2023-11-30
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 4099-4103 )