Correlation Between Bone Mineral Density,Bone Metabolism and Adipocytokines in Patients with Hyperthyroidism

QIAO Hui; DING Hongna; SUN Jun

doi:10.3969/j.issn.1004-437X.2023.22.015

Abstract：Objective To explore the correlation between bone mineral density,bone metabolism and adipocytokines in patients with hyperthyroidism.Methods Eighty-seven patients with hyperthyroidism admitted to the 7th People's Hospital of Zhengzhou from December 2021 to December 2022 were included as the research objects.Patients were divided into normal bone mass group,reduced bone mass group,and osteoporosis group based on the bone mineral density T-value.The levels of adipose cytokine(visfatin,leptin,adiponectin,resistin)and bone metabolism indexes[bone alkaline phosphatase(BALP),osteocalcin(OCN),25-hydroxyvitamin D(25-OH-VD),type Ⅰ collagen cross-linked C-terminal peptide(CTX Ⅰ)]were detected in each group.The correlation between adipocytokines and bone metabolism and bone mineral density in patients with hyperthyroidism was analyzed.Results After bone mineral density examination,among 87 patients with hyperthyroidism,23 cases had normal bone mass,35 cases had decreased bone mass and 29 cases had osteoporosis.There was no statistical differences in gender,age,body mass index,course of disease and disease type among the three groups(P＞0.05).The levels of OCN,BALP,CTX Ⅰ,leptin,adiponectin and resistin in osteoporosis group,osteopenia group and normal osteopenia group decreased in turn,while the levels of 25-OH-VD and visfatin increased in turn,with statistical significance(P＜0.05).Pearson correlation analysis showed that visfatin was negatively correlated with OCN,BALP and CTX Ⅰ(r＜0,P＜0.05)and positively correlated with 25-OH-VD(r＞0,P＜0.05),leptin,adiponectin and resistin were positively correlated with OCN,BALP and CTX Ⅰ(r＞0,P＜0.05)and negatively correlated with 25-OH-VD(r＜0,P＜0.05).Conclusion Bone mineral density of patients with hyperthyroidism is related to bone metabolism and adipocytokines,and clinical treatment measures can be taken according to the level of adipocytokines and bone metabolism to prevent osteoporosis.